Mitochondria are highly dynamic organelles that constantly undergo fission and fusion.
Disruption of mitochondrial dynamics undermines their function and causes several human …

The monolayer of endothelial cells lining the vessel wall forms a semipermeable barrier (in
all tissue except the relatively impermeable blood–brain and inner retinal barriers) that …

Bacterial lipopolysaccharide triggers human caspase-4 (murine caspase-11) to cleave
gasdermin-D and induce pyroptotic cell death. How lipopolysaccharide sequestered in the …

The human non-canonical inflammasome controls caspase-4 activation and gasdermin-D-
dependent pyroptosis in response to cytosolic bacterial lipopolysaccharide (LPS). Since …

Guanylate-binding proteins (GBPs) have recently emerged as central orchestrators of
immunity to infection, inflammation, and neoplastic diseases. Within numerous host cell …

Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in
membrane remodelling, has a critical role in endocytic membrane fission events. The use of …

Mitochondria are double-membraned organelles with variable shapes influenced by
metabolic conditions, developmental stage, and environmental stimuli,,,. Their dynamic …

Guanine nucleotide–binding proteins regulate a variety of processes, including sensual
perception, protein synthesis, various transport processes, and cell growth and …

Dynamins are large GTPases that belong to a protein superfamily that, in eukaryotic cells,
includes classical dynamins, dynamin-like proteins, OPA1, Mx proteins, mitofusins and …

IFN receptor signaling induces cell-autonomous immunity to infections with intracellular
bacterial pathogens. Here, we demonstrate that IFN-inducible guanylate binding protein …