Matrix metalloproteinases in normal pregnancy and preeclampsia
J Chen, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Normal pregnancy is associated with marked hemodynamic and uterine changes that allow
adequate uteroplacental blood flow and uterine expansion for the growing fetus. These …
adequate uteroplacental blood flow and uterine expansion for the growing fetus. These …
Pathogenesis of preeclampsia and therapeutic approaches targeting the placenta
MK Jena, NR Sharma, M Petitt, D Maulik, NR Nayak - Biomolecules, 2020 - mdpi.com
Preeclampsia (PE) is a serious pregnancy complication, affecting about 5–7% of
pregnancies worldwide and is characterized by hypertension and damage to multiple …
pregnancies worldwide and is characterized by hypertension and damage to multiple …
Vascular mechanisms and molecular targets in hypertensive pregnancy and preeclampsia
H Qu, RA Khalil - American Journal of Physiology-Heart and …, 2020 - journals.physiology.org
Preeclampsia is a major complication of pregnancy manifested as hypertension and often
intrauterine growth restriction, but the underlying pathophysiological mechanisms are …
intrauterine growth restriction, but the underlying pathophysiological mechanisms are …
Mechanisms of endothelial dysfunction in hypertensive pregnancy and preeclampsia
JS Possomato-Vieira, RA Khalil - Advances in pharmacology, 2016 - Elsevier
Preeclampsia is a pregnancy-related disorder characterized by hypertension and could lead
to maternal and fetal morbidity and mortality. Although the causative factors and …
to maternal and fetal morbidity and mortality. Although the causative factors and …
RNAi modulation of placental sFLT1 for the treatment of preeclampsia
AA Turanov, A Lo, MR Hassler, A Makris… - Nature …, 2018 - nature.com
Preeclampsia is a placentally induced hypertensive disorder of pregnancy that is associated
with substantial morbidity and mortality to mothers and fetuses. Clinical manifestations of …
with substantial morbidity and mortality to mothers and fetuses. Clinical manifestations of …
Angiogenic factors in preeclampsia: from diagnosis to therapy
SA Karumanchi - Hypertension, 2016 - Am Heart Assoc
Karumanchi Angiogenic Factors and Preeclampsia 1073 to as fenestrations. Although it was
previously known that VEGF induces endothelial fenestrae in culture, 38 experimental data …
previously known that VEGF induces endothelial fenestrae in culture, 38 experimental data …
[HTML][HTML] Uterine artery Doppler in screening for preeclampsia and fetal growth restriction
MA Pedroso, KR Palmer, RJ Hodges… - Revista brasileira de …, 2018 - SciELO Brasil
Objective To perform a comprehensive review of the current evidence on the role of uterine
artery Doppler, isolated or in combination with other markers, in screening for preeclampsia …
artery Doppler, isolated or in combination with other markers, in screening for preeclampsia …
Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1
SM Davis, VN Hariharan, A Lo, AA Turanov… - … Therapy-Nucleic Acids, 2022 - cell.com
Preeclampsia (PE) is a rising, potentially lethal complication of pregnancy. PE is driven
primarily by the overexpression of placental soluble fms-like tyrosine kinase 1 (sFLT1), a …
primarily by the overexpression of placental soluble fms-like tyrosine kinase 1 (sFLT1), a …
Genetic predisposition to preeclampsia is conferred by fetal DNA variants near FLT1, a gene involved in the regulation of angiogenesis
Preeclampsia risk is influenced by both the mother's genetic background and the genetics of
her fetus; however, the specific genes responsible for conferring preeclampsia risk have …
her fetus; however, the specific genes responsible for conferring preeclampsia risk have …
Uteroplacental circulation in normal pregnancy and preeclampsia: functional adaptation and maladaptation
Uteroplacental blood flow increases as pregnancy advances. Adequate supply of nutrients
and oxygen carried by uteroplacental blood flow is essential for the well-being of the mother …
and oxygen carried by uteroplacental blood flow is essential for the well-being of the mother …