Psychedelics, also known as classical hallucinogens, have been investigated for decades
due to their potential therapeutic effects in the treatment of neuropsychiatric and substance …

The neuropsychological effects of naturally occurring psychoactive chemicals have been
recognized for millennia. Hallucinogens, which include naturally occurring chemicals such …

Psilocybin, a psychoactive alkaloid contained in hallucinogenic mushrooms, is nowadays
given a lot of attention in the scientific community as a research tool for modeling psychosis …

The psychedelic 5-HT 2A receptor (5HT2AR) agonist psilocybin (or the active metabolite
psilocin) has emerged as potential useful drug for various neuropsychiatric diseases, with a …

Serotonergic dysfunction is thought to contribute to the pathophysiology of schizophrenia but
the evidence has not been systematically synthesised before. We therefore systematically …

Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors.
Identifying treatment targets is challenging because the diseases are resulting from …

Schizophrenia is a severe brain disorder that usually produces a lifetime of disability. First
generation or typical antipsychotics such as haloperidol and second generation or atypical …

Heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs)
can form multiprotein complexes (heteromers), which can alter the pharmacology and …

Serotonin and glutamate G protein-coupled receptor (GPCR) neurotransmission affects
cognition and perception in humans and rodents. GPCRs are capable of forming …

Antipsychotic drugs remain the standard for schizophrenia treatment. Despite their
effectiveness in treating hallucinations and delusions, prolonged exposure to antipsychotic …