The mechanical properties of soft tissues play a key role in studying human injuries and their
mitigation strategies. While such properties are indispensable for computational modelling …

Heart failure with preserved ejection fraction (HFpEF) is a major, worldwide health-care
problem. Few therapies for HFpEF exist because the pathophysiology of this condition is …

For a complete understanding of a system's processes and each protein's role in health and
disease, it is essential to study protein expression with a spatial resolution, as the exact …

The heart is a central human organ and its diseases are the leading cause of death
worldwide, but an in-depth knowledge of the identity and quantity of its constituent proteins …

T cell autoreactivity is a hallmark of autoimmune diseases but can also benefit self-
maintenance and foster tissue repair. Here, we investigated whether heart-specific T cells …

Inner ear disorders are among the most common congenital abnormalities; however, current
tissue culture models lack the cell type diversity to study these disorders and normal otic …

Background Aging leads to decreased skeletal muscle function in mammals and is
associated with a progressive loss of muscle mass, quality and strength. Age-related muscle …

Direct cardiac reprogramming has emerged as a promising therapeutic approach for cardiac
regeneration. Full chemical reprogramming with small molecules to generate …

Skeletal muscle is a large organ that accounts for up to half the total mass of the human
body. A progressive decline in muscle mass and strength occurs with ageing and in some …

Remarkable progress continues on the annotation of the proteins identified in the Human
Proteome and on finding credible proteomic evidence for the expression of “missing …