Old and new beta-lactamase inhibitors: molecular structure, mechanism of action, and clinical use

D Carcione, C Siracusa, A Sulejmani, V Leoni, J Intra - Antibiotics, 2021 - mdpi.com
The β-lactams have a central place in the antibacterial armamentarium, but the increasing
resistance to these drugs, especially among Gram-negative bacteria, is becoming one of the …

Managing Acinetobacter baumannii infections

J Garnacho-Montero, JF Timsit - Current opinion in infectious …, 2019 - journals.lww.com
Managing Acinetobacter baumannii infections : Current Opinion in Infectious Diseases
Managing Acinetobacter baumannii infections : Current Opinion in Infectious Diseases Log in or …

Portrait of a killer: Uncovering resistance mechanisms and global spread of Acinetobacter baumannii

AK Cain, M Hamidian - PLoS Pathogens, 2023 - journals.plos.org
Antibiotic resistance is a growing global concern in the field of medicine as it renders
bacterial infections difficult to treat and often more severe. Acinetobacter baumannii is a …

β-lactam antibiotics and β-lactamase enzymes inhibitors, part 2: our limited resources

S Alfei, AM Schito - Pharmaceuticals, 2022 - mdpi.com
β-lactam antibiotics (BLAs) are crucial molecules among antibacterial drugs, but the
increasing emergence of resistance to them, developed by bacteria producing β-lactamase …

Virulence Potential and Treatment Options of Multidrug-Resistant (MDR) Acinetobacter baumannii

S Kumar, R Anwer, A Azzi - Microorganisms, 2021 - mdpi.com
Acinetobacter baumannii is an opportunistic pathogen which is undoubtedly known for a
high rate of morbidity and mortality in hospital-acquired infections. A. baumannii causes life …

Treatment of patients with serious infections due to carbapenem‐resistant Acinetobacter baumannii: How viable are the current options?

JN O'Donnell, V Putra, TP Lodise - … : The Journal of Human …, 2021 - Wiley Online Library
This review critically appraises the published microbiologic and clinical data on the
treatment of patients with carbapenem‐resistant Acinetobacter baumannii infections …

The AbaR antibiotic resistance islands found in Acinetobacter baumannii global clone 1–structure, origin and evolution

M Hamidian, RM Hall - Drug Resistance Updates, 2018 - Elsevier
In multiply resistant Acinetobacter baumannii, complex transposons located in the
chromosomal comM gene carry antibiotic and heavy metal resistance determinants. For one …

Durlobactam, a Broad-Spectrum Serine β-lactamase Inhibitor, Restores Sulbactam Activity Against Acinetobacter Species

KM Papp-Wallace, SM McLeod… - Clinical Infectious …, 2023 - academic.oup.com
Sulbactam-durlobactam is a pathogen-targeted β-lactam/β-lactamase inhibitor combination
in late-stage development for the treatment of Acinetobacter infections, including those …

[HTML][HTML] In vitro activity of sulbactam-durlobactam against carbapenem-resistant Acinetobacter baumannii and mechanisms of resistance

J Findlay, L Poirel, M Bouvier, P Nordmann - Journal of Global …, 2022 - Elsevier
ABSTRACT Objectives Multidrug-resistant Acinetobacter baumannii (MDR-Ab), particularly
strains producing oxacillinase (OXA)-type carbapenemases, have rapidly emerged in health …

In vitro activity of sulbactam/durlobactam against global isolates of carbapenem-resistant Acinetobacter baumannii

H Seifert, C Müller, D Stefanik… - Journal of …, 2020 - academic.oup.com
Objectives To evaluate the activity of the novel broad-spectrum serine β-lactamase inhibitor
durlobactam (ETX2514) combined with sulbactam against global isolates of carbapenem …