Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses
M Dobrzyński, LK Nguyen… - Journal of The …, 2014 - royalsocietypublishing.org
We show theoretically and experimentally a mechanism behind the emergence of wide or
bimodal protein distributions in biochemical networks with nonlinear input–output …
bimodal protein distributions in biochemical networks with nonlinear input–output …
Nonlatching positive feedback enables robust bimodality by decoupling expression noise from the mean
Fundamental to biological decision-making is the ability to generate bimodal expression
patterns where 2 alternate expression states simultaneously exist. Here, we use a …
patterns where 2 alternate expression states simultaneously exist. Here, we use a …
Unified probability distribution and dynamics of lead contents in human erythrocytes revealed by single-cell analysis
N Liu, Y Huang, H Zhang, T Wang, C Tao… - Environmental …, 2021 - ACS Publications
Understanding the presence and dynamics of chemical pollutants in individual cells is
fundamentally important for their trafficking, fate, and toxicity in humans. The presence of …
fundamentally important for their trafficking, fate, and toxicity in humans. The presence of …
Nonlinear biochemical signal processing via noise propagation
Single-cell studies often show significant phenotypic variability due to the stochastic nature
of intra-cellular biochemical reactions. When the numbers of molecules, eg, transcription …
of intra-cellular biochemical reactions. When the numbers of molecules, eg, transcription …
Mathematical model reveals that heterogeneity in the number of ion transporters regulates the fraction of mouse sperm capacitation
Capacitation is a complex maturation process mammalian sperm must undergo in the
female genital tract to be able to fertilize an egg. This process involves, amongst others …
female genital tract to be able to fertilize an egg. This process involves, amongst others …
Controlling E. coli gene expression noise
Intracellular protein copy numbers show significant cell-to-cell variability within an isogenic
population due to the random nature of biological reactions. Here we show how the …
population due to the random nature of biological reactions. Here we show how the …
Process simulation of complex biological pathways in physical reactive space and reformulated for massively parallel computing platforms
Biological systems encompass complexity that far surpasses many artificial systems.
Modeling and simulation of large and complex biochemical pathways is a computationally …
Modeling and simulation of large and complex biochemical pathways is a computationally …
Autoregulation and heterogeneity in expression of human Cripto-1
Cripto-1 (CR-1) is involved in various processes in embryonic development and cancer.
Multiple pathways regulate CR-1 expression. Our present work demonstrates a possible …
Multiple pathways regulate CR-1 expression. Our present work demonstrates a possible …
Kinetic models of biochemical signaling networks
M Bouhaddou, MR Birtwistle - Systems Pharmacology and …, 2016 - Springer
Kinetic models of biochemical signaling networks are a mechanistic description of
pharmacodynamics, and thus are potentially well-poised to fill gaps in the drug development …
pharmacodynamics, and thus are potentially well-poised to fill gaps in the drug development …
Modelo matemático para la capacitación de espermatozoides en la fecundación de mamíferos
AAA GARCIA - 2021 - riaa.uaem.mx
La capacitación es un proceso de maduración complejo el cual los espermatozoides de
mamífero deben atravesar durante su transito y residencia en el tracto reproductor femenino …
mamífero deben atravesar durante su transito y residencia en el tracto reproductor femenino …