Somatostatin is a peptide with a potent and broad antisecretory action, which makes it an
invaluable drug target for the pharmacological management of pituitary adenomas and …

Peptide receptors involved in pathophysiological processes represent promising therapeutic
targets. Neuropeptide somatostatin (SST) is produced by specialized cells in a large number …

Gastroenteropancreatic neuroendocrine neoplasms are heterogeneous in their clinical
behavior and require therapies specially tailored according to staging, grading, origin and …

Somatostatin analogs (SA) are the standard of care for controlling symptoms of patients with
functional gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs). SA control …

Objectives: To evaluate somatostatin receptor 2A (SSTR2A) and dopamine receptor 2 (DR2)
protein expression in somatotropinomas and to relate it to response to somatostatin …

Prolactin is best known for its actions on the mammary gland. However, circulating prolactin
is also detected in males and its receptor (PRLR) is expressed in the prostate, suggesting …

Somatostatin (SS) and dopamine (DA) receptors have been highlighted as two critical
regulators in the negative control of hormonal secretion in a wide group of human endocrine …

The most recent World Health Organization classification of renal neoplasms encompassed
nearly 50 distinctive renal neoplasms. Different histological subtypes have different clinical …

Because cancer cell invasion is a critical determinant of metastasis, targeting invasion is a
viable approach to prevent metastasis. Utilizing a novel three-dimensional high-throughput …

A combination of basic research observations concerning the interaction of somatostatin
(SST) and dopamine (DA) receptors, and clinical reports of enhanced efficacy of combined …