Process analytical technology tools for monitoring pharmaceutical unit operations: a control strategy for continuous process verification

EJ Kim, JH Kim, MS Kim, SH Jeong, DH Choi - Pharmaceutics, 2021 - mdpi.com
Various frameworks and methods, such as quality by design (QbD), real time release test
(RTRT), and continuous process verification (CPV), have been introduced to improve drug …

Continuous manufacturing in pharmaceutical process development and manufacturing

CL Burcham, AJ Florence… - Annual review of …, 2018 - annualreviews.org
The pharmaceutical industry has found new applications for the use of continuous
processing for the manufacture of new therapies currently in development. The …

Recent progress in continuous manufacturing of oral solid dosage forms

V Vanhoorne, C Vervaet - International Journal of Pharmaceutics, 2020 - Elsevier
Continuous drug product manufacturing is slowly being implemented in the pharmaceutical
industry. Although the benefits related to the quality and cost of continuous manufacturing …

Twin screw granulation—A literature review

TC Seem, NA Rowson, A Ingram, Z Huang, S Yu… - Powder Technology, 2015 - Elsevier
This review article addresses the currently available literature on twin screw granulation
(TSG). TSG is an emerging technology rapidly gaining interest in the pharmaceutical …

A comprehensive review on process and engineering aspects of pharmaceutical wet granulation

P Suresh, I Sreedhar, R Vaidhiswaran… - Chemical Engineering …, 2017 - Elsevier
Wet granulation is a very important unit operation that finds applications in many industries
mainly pharmaceutical and chemical industries. Various granulation technologies in batch …

[HTML][HTML] Effect of particle size distribution on flowability of granulated lactose

Y Kudo, M Yasuda, S Matsusaka - Advanced Powder Technology, 2020 - Elsevier
The flowability of powders used in tableting significantly affects tablet weight and content
uniformity of active pharmaceutical ingredients. Use of granulated materials instead of …

[图书][B] Continuous manufacturing of pharmaceuticals

P Kleinebudde, J Khinast, J Rantanen - 2017 - books.google.com
A comprehensive look at existing technologies and processes for continuous manufacturing
of pharmaceuticals As rising costs outpace new drug development, the pharmaceutical …

Recent trends and future perspective of pharmaceutical wet granulation for better process understanding and product development

P Thapa, J Tripathi, SH Jeong - Powder Technology, 2019 - Elsevier
Current trends in pharmaceutical wet granulation have been shifted from traditional
approach to systematic and modern approaches, enabling the production of highly …

Model-based analysis of high shear wet granulation from batch to continuous processes in pharmaceutical production–a critical review

A Kumar, KV Gernaey, T De Beer, I Nopens - European Journal of …, 2013 - Elsevier
The manufacturing of pharmaceutical dosage forms, which has traditionally been a batch-
wise process, is now also transformed into a series of continuous operations. Some …

Impact of screw configuration on the particle size distribution of granules produced by twin screw granulation

J Vercruysse, A Burggraeve, M Fonteyne… - International journal of …, 2015 - Elsevier
Twin screw granulation (TSG) has been reported by different research groups as an
attractive technology for continuous wet granulation. However, in contrast to fluidized bed …