Tactile sensory information from facial whiskers provides nocturnal tunnel-dwelling rodents,
including mice and rats, with important spatial and textural information about their immediate …

Pyramidal neurons are characterized by their distinct apical and basal dendritic trees and
the pyramidal shape of their soma. They are found in several regions of the CNS and …

Studies of visual processing in rodents have conventionally been performed on
anesthetized animals, precluding examination of the effects of behavior on visually evoked …

Neural computation involves diverse types of GABAergic inhibitory interneurons that are
integrated with excitatory (E) neurons into precisely structured circuits. To understand how …

Primary sensory cortex is thought to process incoming sensory information, while decision
variables important for driving behavior are assumed to arise downstream in the processing …

Genetic methods available in mice are likely to be powerful tools in dissecting cortical
circuits. However, the visual cortex, in which sensory coding has been most thoroughly …

Optical methods capable of manipulating neural activity with cellular resolution and
millisecond precision in three dimensions will accelerate the pace of neuroscience research …

In the rodent vibrissal system, active sensation and sensorimotor integration are mediated in
part by connections between barrel cortex and vibrissal motor cortex. Little is known about …

Spontaneous activity plays an important role in the function of neural circuits. Although many
similarities between spontaneous and sensory-evoked neocortical activity have been …

The advent of unbiased recording and imaging techniques to evaluate firing activity across
neocortical neurons has revealed substantial heterogeneity in response properties in vivo …