Each follicle represents the basic functional unit of the ovary. From its very initial stage of
development, the follicle consists of an oocyte surrounded by somatic cells. The oocyte …

Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in reproductive-aged
women. Clinical manifestations include hyperandrogenism, chronic anovulation, polycystic …

Emerging studies indicate that the Hippo pathway, a highly conserved pathway that
regulates organ size control, plays an important role in governing ovarian physiology …

Although the role of the Hippo signaling pathway in development and tumorigenesis has
been extensively studied in multiple organs, its role in ovarian follicle development remains …

The ovary is an interesting organ that shows major structural changes within a short period
of time during each reproductive cycle. Follicle development is controlled by local paracrine …

Abstract Yes-associated protein 1 (YAP1) is a major component of the Hippo signaling
pathway. Although the exact extracellular signals that control the Hippo pathway are …

Clarifying the molecular mechanisms by which primordial follicles are initiated is crucial for
the prevention and treatment of female infertility and ovarian dysfunction. The Hippo …

One of the most widely used types of assisted reproduction technology is the in vitro
fertilization (IVF), in which women undergo controlled ovarian stimulation through the …

Purpose To provide a commentary on our understanding of the role that the Hippo signaling
pathway may play in patients with polycystic ovarian syndrome (PCOS) and how this …

Disruption of iron homeostasis plays a negative role in follicle development. The dynamic
changes in follicle growth are dependent on Hippo/YAP signaling and mechanical forces …