Metabolic messengers: tumour necrosis factor
JK Sethi, GS Hotamisligil - Nature metabolism, 2021 - nature.com
Tumour necrosis factor (TNF) is a classical, pleiotropic pro-inflammatory cytokine. It is also
the first 'adipokine'described to be produced from adipose tissue, regulated in obesity and …
the first 'adipokine'described to be produced from adipose tissue, regulated in obesity and …
Impact of diabetes in patients diagnosed with COVID-19
COVID-19 is a disease caused by the coronavirus SARS-CoV-2 (Severe Acute Respiratory
Syndrome Coronavirus-2), known as a highly contagious disease, currently affecting more …
Syndrome Coronavirus-2), known as a highly contagious disease, currently affecting more …
Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment
J Amar, C Chabo, A Waget, P Klopp… - EMBO molecular …, 2011 - embopress.org
A fat‐enriched diet modifies intestinal microbiota and initiates a low‐grade inflammation,
insulin resistance and type‐2 diabetes. Here, we demonstrate that before the onset of …
insulin resistance and type‐2 diabetes. Here, we demonstrate that before the onset of …
High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse
S Ding, MM Chi, BP Scull, R Rigby, NMJ Schwerbrock… - PloS one, 2010 - journals.plos.org
Background Obesity induced by high fat (HF) diet is associated with inflammation which
contributes to development of insulin resistance. Most prior studies have focused on adipose …
contributes to development of insulin resistance. Most prior studies have focused on adipose …
Macrophage recruitment in obese adipose tissue
Y Bai, Q Sun - Obesity Reviews, 2015 - Wiley Online Library
Obesity is characterized as a chronic state of low‐grade inflammation with progressive
immune cell infiltration into adipose tissues. Adipose tissue macrophages play critical roles …
immune cell infiltration into adipose tissues. Adipose tissue macrophages play critical roles …
[HTML][HTML] TNF-α and adipocyte biology
WP Cawthorn, JK Sethi - FEBS letters, 2008 - Elsevier
Dyslipidemia and insulin resistance are commonly associated with catabolic or
lipodystrophic conditions (such as cancer and sepsis) and with pathological states of …
lipodystrophic conditions (such as cancer and sepsis) and with pathological states of …
ADAM-17: the enzyme that does it all
M Gooz - Critical reviews in biochemistry and molecular biology, 2010 - Taylor & Francis
This review focuses on the role of ADAM-17 in disease. Since its debut as the tumor
necrosis factor converting enzyme (TACE), ADAM-17 has been reported to be an …
necrosis factor converting enzyme (TACE), ADAM-17 has been reported to be an …
TNF-α and obesity
T Tzanavari, P Giannogonas, KP Karalis - TNF Pathophysiology, 2010 - karger.com
Obesity, an epidemic of our times with rates rising to alarming levels, is associated with
comorbidities including cardiovascular diseases, arthritis, certain cancers, and degenerative …
comorbidities including cardiovascular diseases, arthritis, certain cancers, and degenerative …
Pharmacological and nutritional agents promoting browning of white adipose tissue
The role of brown adipose tissue in the regulation of energy balance and maintenance of
body weight is well known in rodents. Recently, interest in this tissue has re-emerged due to …
body weight is well known in rodents. Recently, interest in this tissue has re-emerged due to …
MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1
R Menghini, V Casagrande, M Cardellini, E Martelli… - Circulation, 2009 - Am Heart Assoc
Background—Aging is a major risk factor for the development of atherosclerosis and
coronary artery disease. Through a microarray approach, we have identified a microRNA …
coronary artery disease. Through a microarray approach, we have identified a microRNA …