Cancer-associated fibroblasts (CAFs) are the predominant components of the tumor
microenvironment (TME) and influence cancer hallmarks, but without systematic …

Myeloid-derived suppressor cells (MDSCs) constitute a plastic and heterogeneous cell
population among immune cells within the tumour microenvironment (TME) that support …

Hepatocellular carcinoma (HCC) is an immunotherapy-resistant malignancy characterized
by high cellular heterogeneity. The diversity of cell types and the interplay between tumor …

The immunomodulatory imide drug (IMiD) class, which includes the founding drug member
thalidomide and later generation drugs, lenalidomide and pomalidomide, has dramatically …

Background We assessed the mechanism by which multiple myeloma (MM) shapes the
bone marrow (BM) microenvironment and affects MΦ polarization. Methods In vivo xenograft …

Targeting myeloid cells, especially microglia, for the treatment of neuroinflammatory
diseases such as multiple sclerosis (MS), is underappreciated. Our in silico drug screening …

Microphthalmia-associated transcription factor (MITF), a basic helix-loop-helix leucine zipper
transcription factor (bHLH-Zip), has been identified as a melanocyte-specific transcription …

The tumor immune microenvironment plays a vital role in the metastasis of colorectal cancer.
As one of the most important immune cells, macrophages act as phagocytes, patrol the …

Simple Summary Multiple myeloma (MM) is the second-most common blood cancer and is
currently incurable despite recent advances in treatment. The immune cells which are …

Simple Summary The growing interest in immunotherapy for the treatment of multiple
myeloma demands a deep knowledge of the complex interactions between malignant and …