The majority of breast cancers express the estrogen receptor (ERα) and agents targeting this
pathway represent the main treatment modality. Endocrine therapy has proven successful in …

Cancer genome-sequencing studies have revealed a remarkably high prevalence of
mutations in genes encoding subunits of the SWI/SNF chromatin-remodelling complexes …

Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by
removing acetyl groups from histones and other protein regulatory factors, with functional …

Genes encoding SWI/SNF chromatin remodeling complex subunits are collectively mutated
in approximately 20% of human cancers. ARID1A is a SWI/SNF subunit gene whose protein …

Natural killer/T cell lymphoma (NKTCL) is an aggressive and heterogeneous entity of non-
Hodgkin lymphoma, strongly associated with Epstein-Barr virus (EBV) infection. To identify …

Ovarian cancer is the deadliest gynecologic malignancy, with a 5-year survival rate of
approximately 47%, a number that has remained constant over the past two decades. Early …

Mutations in ARID1A rank among the most common molecular aberrations in human cancer.
However, oncogenic consequences of ARID1A mutation in human cells remain poorly …

Multi-subunit ATPase-dependent chromatin remodelling complexes SWI/SNF
(switch/sucrose non-fermentable) are fundamental epigenetic regulators of gene …

Abstract Changes in chromatin structure mediated by ATP-dependent nucleosome
remodelers and histone modifying enzymes are integral to the process of gene regulation …