Despite the high regenerative capacity of bone tissue, there are some cases where bone
repair is insufficient for a complete functional and structural recovery after damage. Current …

Introduction: The unique structure of bone and cartilage makes the systemic delivery of free
drugs to those connective tissues very challenging. Consequently, effective and targeted …

The renal actions of parathyroid hormone (PTH) promote 1, 25-vitamin D generation;
however, the signaling mechanisms that control PTH-dependent vitamin D activation remain …

Abstract Purpose of Review Compared with the current standard of implanting bone
anabolics for fracture repair, bone fracture-targeted anabolics would be more effective, less …

Parathyroid hormone (PTH) has been a major contributor to the anabolic therapy for
osteoporosis, but its delivery to bone without losing activity and avoiding adverse local …

Abstract Purpose of Review The skeletal system provides an important role to support body
structure and protect organs. The complexity of its architecture and components makes it …

Rheumatoid arthritis (RA) is a chronic inflammatory condition of synovial joints that causes
disability and systemic complications. Ang-(1-7), one of the main peptides in the renin …

The development of bone-targeting drug delivery systems holds immense promise for
improving the treatment of skeletal diseases. By precisely delivering therapeutic agents to …

Osteoporosis is a bone incapacitating malady which globally accounts for over hundred
million fractures annually. Therapeutic interventions for management of osteoporosis are …

Rheumatoid arthritis (RA) is an autoimmune inflammatory bone destructive disorder that is
orchestrated by multiple systems in the body, including Renin-Angiotensin System (RAS) …