Diabetic foot ulcer (DFU) is one of the most common complications of diabetes, bringing
physical and mental challenges for patients due to the lack of efficient curative therapy …

Marine polysaccharides (MPs) are exceptional bioactive materials that possess unique
biochemical mechanisms and pharmacological stability, making them ideal for various …

Burns and other traumatic injuries represent a substantial biomedical burden. The current
standard of care for deep injuries is autologous split-thickness skin grafting (STSG), which …

Osteoarthritis (OA) is the most common joint disease, affecting over 300 million people world-
wide. Accumulating evidence attests to the important roles of the immune system in OA …

Tissue fibrosis affects multiple organs and involves a master-regulatory role of macrophages
which respond to an initial inflammatory insult common in all forms of fibrosis. The recently …

Biomaterials are one of efficient treatment options for tissue defects in regenerative
medicine. Compared to synthetic materials which tend to induce chronic inflammatory …

After implantation of a biomaterial, both the host immune system and properties of the
material determine the local immune response. Through triggering or modulating the local …

Hydrogel-based tissue-engineered skin has attracted increased attention due to its potential
to restore the structural integrity and functionality of skin. However, the mechanical …

Chronic wounds impose a significant healthcare burden to a broad patient population. Cell-
based therapies, while having shown benefits for the treatment of chronic wounds, have not …

Infectious diabetic ulcers (IDU) require anti‐infection, angiogenesis, and nerve regeneration
therapy; however, the latter has received comparatively less research attention than the …