Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The
spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases …

Cryopreservation is an expanding strategy to allow not only fertility preservation for
individuals who need such procedures because of gonadotoxic treatments, active duty in …

Male factor is responsible for up to 50% of infertility cases in the world. Semen analysis is
considered the cornerstone of laboratory evaluation of male infertility, but it has its own …

Spermatozoa have the task to deliver an intact paternal genome to the oocyte and to support
a successful embryo development. The high levels of sperm DNA fragmentation (sDF) found …

DNA integrity is considered an important parameter of semen quality and is of significant
value as a predictor of male fertility. Currently, there are several methods that can assess …

In the complex and dynamic processes of replication, transcription, and translation of DNA
molecules, a large number of replication errors or damage can occur which lead to …

Introduction Human sperm freezing is very widely used for male fertility preservation. This
procedure consists in adding cryoprotectants to the spermatozoa followed by cooling and …

The modern approach to cancer management has evolved into a multidisciplinary initiative
focused not only on cancer specific and overall survival, but also patient quality of life and …

Testicular cancer (TC) is one of the most treatable of all malignancies and the management
of the quality of life of these patients is increasingly important, especially with regard to their …

Fertility is a growing healthcare issue for a rising number of cancer survivors. In men, cancer
itself and its treatment can negatively affect spermatogenesis by targeting the dividing …