Tumor mutational burden (TMB) has been reported to determine the response to
immunotherapy, thus affecting the patient's prognosis in many cancers. However, it is …

Noninvasive examination is an emerging area in the field of neuro-oncology. Liquid biopsy
captures the landscape of genomic alterations of brain tumors and revolutionizes the …

PIWI-interacting RNAs (piRNAs) are a less-studied class of small non-coding RNAs
approximately 24–31 nucleotides in length. They express in germline and somatic cells and …

Common genetic mutations are absent in neuroblastoma, one of the most common
childhood tumours. As a demethylase of 5‐methylcytosine (m5C) modification, TET1 plays …

Background Cancer is a major cause of death, and its early identification and intervention
have potential for clinical actionability and benefits for human health. The studies using …

Objectives Cancer and diabetes are two diseases known to bypass socio-demographic
segregation, hence the increased focus on their molecular mechanism for therapeutic …

Background The genetic background of cancer remains complex and challenging to
integrate. Many somatic mutations within genes are known to cause and drive cancer, while …

Breast cancer risk have been discussed to be associated with polymorphisms in genes as
well as abnormal DNA damage repair function. This study aims to assess the relationship …

HER2-targeted therapy has improved breast cancer survival, but treatment resistance and
disease prevention remain major challenges. Genes that enable HER2/Neu oncogenesis …

Neuroblastoma is the most prevalent extracranial solid tumor among children and exhibits
remarkable heterogeneity. The methylation of cytosine to form 5-methylcytosine (m5C) is the …