Accumulation of amyloid β-peptide (Aβ) is a driver of Alzheimer's disease (AD). Amyloid
precursor protein (App) knock-in mouse models recapitulate AD-associated Aβ pathology …

Despite decades of intense research, disease-modifying therapeutic approaches for
Alzheimer's disease (AD) are still very much needed. Apart from the extensively analyzed …

The presymptomatic phase of Alzheimer disease (AD) starts with the deposition of amyloid-β
in the cortex and begins a decade or more before the emergence of cognitive decline. The …

Abstract The oxysterol 27-hydroxycholesterol (27OHC) is produced by the enzyme sterol 27-
hydroxylase (Cyp27A1) and is mainly catabolized to 7α-Hydroxy-3-oxo-4-cholestenoic acid …

INTRODUCTION Memory‐associated neural circuits produce oscillatory events including
theta bursts (TBs), sleep spindles (SPs), and slow waves (SWs) in sleep …

The amyloid plaque niche is a pivotal hallmark of Alzheimer's disease (AD). Here, we
employ two high-resolution spatial transcriptomics (ST) platforms, CosMx and Spatial …

Circadian disruption predicts poor cancer prognosis, yet how circadian disruption is sensed
in sleep-deficiency (SD)-enhanced tumorigenesis remains obscure. Here, we show fatty …

Abstract Background Infection with Angiostrongylus cantonensis (AC) in humans or mice
can lead to severe eosinophilic meningitis or encephalitis, resulting in various neurological …

Since 1975, the incidence of obesity has increased to epidemic proportions, and the number
of patients with obesity has quadrupled. Obesity is a major risk factor for developing other …

Electroencephalography (EEG) of small animal models of brain disorders is the powerful
method of neurophysiology that requires efficient, low cost and flexible instrumentation. Most …