A large number of diverse mechanisms that lead to cytoprotection have been described to
date. Perhaps, not surprisingly, the role of mitochondria in these phenomena is notable. In …

Cystic fibrosis is a hereditary disease that mainly affects secretory organs in humans. It is
caused by mutations in the gene encoding CFTR with the most common phenylalanine …

The field of mitochondrial ion channels underwent a rapid development during the last
decade, thanks to the molecular identification of some of the nuclear-encoded organelle …

Mitochondria are bioenergetic organelles with a plethora of fundamental functions ranging
from metabolism and ATP production to modulation of signaling events leading to cell …

Ion channels are non-conventional, druggable oncological targets. The intermediate-
conductance calcium-dependent potassium channel (KCa3. 1) is highly expressed in the …

Abstract Ca2+-activated K+ channels of intermediate conductance (IK) are frequently
overexpressed in breast cancer (BC) cells, while IK channel depletion reduces BC cell …

The stable gastric pentadecapeptide BPC 157 counteracts various venous occlusion-
induced syndromes. Summarized are all these arguments, in the Robert's cytoprotection …

Objectives Acute myocardial ischemia is one of the major causes of illness in western
society. Reduced coronary blood supply leads to cell death and loss of cardiomyocyte …

Potassium ions can cross both the outer and inner mitochondrial membranes by means of
multiple routes. A few potassium-permeable ion channels exist in the outer membrane, while …

Mitochondrial ion channels are emerging oncological targets, as modulation of these ion-
transporting proteins may impact on mitochondrial membrane potential, efficiency of …