Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …

Iron is a critical component of many cellular functions including DNA replication and repair,
and it is essential for cell vitality. As an essential element, iron is critical for maintaining …

Demanded as an essential trace element that supports cell growth and basic functions, iron
can be harmful and cancerogenic though. By exchanging between its different oxidized …

Iron plays an essential role in normal biological processes: The generation of cellular
energy, oxygen transport, DNA synthesis and repair are all processes that require iron …

As an important trace element, iron plays an essential role in many biology processes like
cell proliferation, metabolism, and mitochondrial function. However, the disruption of iron …

Background: Among head and neck squamous cell carcinomas (HNSCCs), hypopharyngeal
squamous cell carcinoma (HPSCC) has the worst prognosis. Iron metabolism, which plays a …

There is new and increasing evidence from in vitro, in vivo and clinical studies implicating
the pivotal role of iron and associated metabolic pathways in the initiation, progression and …

Iron is an essential mineral that serves as a prosthetic group for a variety of proteins involved
in vital cellular processes. The iron economy within humans is highly conserved in that there …

The historical insights and background of the discovery, development and clinical use of
deferiprone (L1) and the maltol–iron complex, which were discovered over 40 years ago …

Iron chelators have long been a target of interest as anticancer agents. Iron is an important
cellular resource involved in cell replication, metabolism and growth. Iron metabolism is …