[HTML][HTML] Host-directed therapies for bacterial and viral infections
SHE Kaufmann, A Dorhoi, RS Hotchkiss… - Nature reviews Drug …, 2018 - nature.com
Despite the recent increase in the development of antivirals and antibiotics, antimicrobial
resistance and the lack of broad-spectrum virus-targeting drugs are still important issues and …
resistance and the lack of broad-spectrum virus-targeting drugs are still important issues and …
[HTML][HTML] Tuberculosis and lung damage: from epidemiology to pathophysiology
S Ravimohan, H Kornfeld, D Weissman… - European respiratory …, 2018 - Eur Respiratory Soc
A past history of pulmonary tuberculosis (TB) is a risk factor for long-term respiratory
impairment. Post-TB lung dysfunction often goes unrecognised, despite its relatively high …
impairment. Post-TB lung dysfunction often goes unrecognised, despite its relatively high …
Post-tuberculosis lung disease: clinical review of an under-recognised global challenge
An estimated 58 million people have survived tuberculosis since 2000, yet many of them will
suffer from post-tuberculosis lung disease (PTLD). PTLD results from a complex interplay …
suffer from post-tuberculosis lung disease (PTLD). PTLD results from a complex interplay …
[HTML][HTML] Inflammation-mediated tissue damage in pulmonary tuberculosis and host-directed therapeutic strategies
D Tiwari, AR Martineau - Seminars in Immunology, 2023 - Elsevier
Abstract Treatment of tuberculosis (TB) involves the administration of anti-mycobacterial
drugs for several months. The emergence of drug-resistant strains of Mycobacterium …
drugs for several months. The emergence of drug-resistant strains of Mycobacterium …
Cavitary tuberculosis: the gateway of disease transmission
ME Urbanowski, AA Ordonez… - The Lancet Infectious …, 2020 - thelancet.com
Tuberculosis continues to be a major threat to global health. Cavitation is a dangerous
consequence of pulmonary tuberculosis associated with poor outcomes, treatment relapse …
consequence of pulmonary tuberculosis associated with poor outcomes, treatment relapse …
[HTML][HTML] Tuberculosis as a three-act play: A new paradigm for the pathogenesis of pulmonary tuberculosis
RL Hunter - Tuberculosis, 2016 - Elsevier
Lack of access to human tissues with untreated tuberculosis (TB) has forced generations of
researchers to use animal models and to adopt a paradigm that granulomas are the …
researchers to use animal models and to adopt a paradigm that granulomas are the …
Hypoxia and tissue destruction in pulmonary TB
M Belton, S Brilha, R Manavaki, F Mauri, K Nijran… - Thorax, 2016 - thorax.bmj.com
Background It is unknown whether lesions in human TB are hypoxic or whether this
influences disease pathology. Human TB is characterised by extensive lung destruction …
influences disease pathology. Human TB is characterised by extensive lung destruction …
Mouse models of human TB pathology: roles in the analysis of necrosis and the development of host-directed therapies
I Kramnik, G Beamer - Seminars in immunopathology, 2016 - Springer
A key aspect of TB pathogenesis that maintains Mycobacterium tuberculosis in the human
population is the ability to cause necrosis in pulmonary lesions. As co-evolution shaped M …
population is the ability to cause necrosis in pulmonary lesions. As co-evolution shaped M …
Host-directed therapies: modulating inflammation to treat tuberculosis
Following infection with Mycobacterium tuberculosis, the causative agent of tuberculosis
(TB), most human hosts are able to contain the infection and avoid progression to active TB …
(TB), most human hosts are able to contain the infection and avoid progression to active TB …
The Immune Response to Mycobacterium tuberculosis in HIV-1-Coinfected Persons
Globally, about 36.7 million people were living with HIV infection at the end of 2015. The
most frequent infection co-occurring with HIV-1 is Mycobacterium tuberculosis—374,000 …
most frequent infection co-occurring with HIV-1 is Mycobacterium tuberculosis—374,000 …