miRNAs as potential game-changers in head and neck cancer: Future clinical and medicinal uses

HA El-Mahdy, AM Mohamadin, AI Abulsoud… - … -Research and Practice, 2023 - Elsevier
Head and neck cancers (HNCs) are a group of heterogeneous tumors formed most
frequently from epithelial cells of the larynx, lips, oropharynx, nasopharynx, and mouth …

The molecular basis and therapeutic aspects of cisplatin resistance in oral squamous cell carcinoma

Y Cheng, S Li, L Gao, K Zhi, W Ren - Frontiers in oncology, 2021 - frontiersin.org
Oral squamous cell carcinoma (OSCC) is a kind of malignant tumors with low survival rate
and prone to have early metastasis and recurrence. Cisplatin is an alkylating agent which …

Autophagy-regulating microRNAs and cancer

D Gozuacik, Y Akkoc, DG Ozturk, M Kocak - Frontiers in oncology, 2017 - frontiersin.org
Macroautophagy (autophagy herein) is a cellular stress response and a survival pathway
that is responsible for the degradation of long-lived proteins, protein aggregates, as well as …

Liquid biopsy: miRNA as a potential biomarker in oral cancer

S Mazumder, S Datta, JG Ray, K Chaudhuri… - Cancer …, 2019 - Elsevier
Oral cancer is one of the leading cancers in South-Asian countries. Despite the easy access
of the oral cavity, the detection and five year survival rates of OSCC patients are dismal …

Exosomes containing miR-21 transfer the characteristic of cisplatin resistance by targeting PTEN and PDCD4 in oral squamous cell carcinoma

T Liu, G Chen, D Sun, M Lei, Y Li, C Zhou… - Acta biochimica et …, 2017 - academic.oup.com
Resistance to chemotherapy remains a major obstacle for the effective treatment of oral
squamous cell carcinoma (OSCC). Evidence for the involvement of exosomes as important …

MicroRNA as a novel biomarker in the diagnosis of head and neck cancer

J Kabzinski, M Maczynska, I Majsterek - Biomolecules, 2021 - mdpi.com
Head and neck squamous cell carcinoma is the sixth most common cancer worldwide, with
890,000 new cases and 450,000 deaths in 2018, and although the survival statistics for …

MicroRNAs as important players and biomarkers in oral carcinogenesis

A Min, C Zhu, S Peng, S Rajthala… - BioMed research …, 2015 - Wiley Online Library
Oral cancer, represented mainly by oral squamous cell carcinoma (OSCC), is the eighth
most common type of human cancer worldwide. The number of new OSCC cases is …

microRNAs in oral cancer: Moving from bench to bed as next generation medicine

W D'Souza, A Kumar - Oral oncology, 2020 - Elsevier
Oral cancer is the thirteenth most common cancer in the world, with India contributing to 33%
of the global burden. Lack of specific non-invasive markers, non-improvement in patient …

The PDCD4/miR-21 pathway in medullary thyroid carcinoma

G Pennelli, F Galuppini, S Barollo, E Cavedon… - Human pathology, 2015 - Elsevier
Summary Programmed cell death 4 (PDCD4) is a tumor suppressor gene involved in
tumorogenesis. MicroRNA-21 (miR-21) specifically targets PDCD4, and recent studies …

miR‐15a‐5p and miR‐21‐5p contribute to chemoresistance in cytogenetically normal acute myeloid leukaemia by targeting PDCD4, ARL2 and BTG2

V Vandewalle, A Essaghir, E Bollaert… - Journal of cellular …, 2021 - Wiley Online Library
Cytarabine and daunorubicin are old drugs commonly used in the treatment of acute
myeloid leukaemia (AML). Refractory or relapsed disease because of chemotherapy …