Managing efficacy and toxicity of drugs: Targeted delivery and excretion

P Kundu, S Das, N Chattopadhyay - International Journal of Pharmaceutics, 2019 - Elsevier
Medicine is a natural companion of mankind in the present era for mere survival from the
deadly diseases in ever-increasing polluted environments. Hence, in recent years, major …

Evidence for dual site binding of nile blue a toward DNA: Spectroscopic, thermodynamic, and molecular modeling studies

M Mohammad, H Al Rasid Gazi, K Pandav… - ACS …, 2021 - ACS Publications
Binding of Nile Blue (NB) with calf thymus DNA has been studied using molecular modeling,
spectroscopic, and thermodynamic techniques. Our study revealed that NB binds to the DNA …

Probing the intercalation of noscapine from sodium dodecyl sulfate micelles to calf thymus deoxyribose nucleic acid: a mechanistic approach

N Maurya, KA Alzahrani, R Patel - ACS omega, 2019 - ACS Publications
Noscapine (NOS) is efficient in inhibiting cellular proliferation and induces apoptosis in
nonsmall cell, lung, breast, lymphatic, and prostate cancers. The micelle-assisted drug …

Exploring the Nucleobase-Specific Hydrophobic Interaction of Cryptolepine Hydrate with RNA and Its Subsequent Sequestration

A Nandy, S Shekhar, BK Paul, S Mukherjee - Langmuir, 2021 - ACS Publications
The study of the interactions of drug molecules with genetic materials plays a key role
underlying the development of new drugs for many life-threatening diseases in …

A comparison on the biochemical activities of Fluorescein disodium, Rose Bengal and Rhodamine 101 in the light of DNA binding, antimicrobial and cytotoxic study

M Mohammad, I Saha, K Pal, P Karmakar… - Journal of …, 2022 - Taylor & Francis
Abstract Biochemical activities of Fluorescein, Rose Bengal and Rhodamine 101 were
studied by DNA binding, antibacterial and cytotoxic studies. DNA binding studies were done …

Ionic liquid green assembly-mediated migration of piperine from calf-thymus DNA: a new possibility of the tunable drug delivery system

N Maurya, ZA Parray, JK Maurya, A Islam, R Patel - ACS omega, 2019 - ACS Publications
Biocompatible surface-active ionic liquid (SAIL) was used first to study the deintercalation
process of a well-known natural compound piperine (PIP) as an anticancer drug, obtained …

Origin of unusually high fluorescence anisotropy of 3-hydroxyflavone in water: Formation of probe–solvent cage-like cluster

S Das, S Chakrabarty… - The Journal of Physical …, 2019 - ACS Publications
Based on the unusually high fluorescence anisotropy (FA) of 3-hydroxyflavone (3HF) in
water medium in contrast to the very low FA of its methoxy counterpart (3MF), our proposition …

Exploring the binding interaction of Bis-benzimidazoles with BSA and relocation of bound drug from BSA to DNA

P Das, P Mandal, D Shit, S Pramanik - Journal of Molecular Structure, 2024 - Elsevier
In recent years Bis-benzimidazole derivatives have gained much research interest due to
their regulatory role in biological reactions to control diseases. Therefore, probing the …

Liposome‐Based Delivery of a Bis‐benzimidazole Derivative to Duplex DNA: A Spectroscopic Study

D Shit, P Mandal, P Das, S Pramanik - ChemistrySelect, 2024 - Wiley Online Library
Due to the immense pharmacological significance, the interaction of small molecules with
liposome and the exact knowledge of their binding location and distribution within the lipid …

Unraveling the binding interaction of a bioactive pyrazole-based probe with serum proteins: Relative concentration dependent 1: 1 and 2: 1 probe-protein …

P Kundu, N Chattopadhyay - Biophysical Chemistry, 2018 - Elsevier
Molecular interactions and binding of probes/drugs with biomacromolecular systems are of
fundamental importance in understanding the mechanism of action and hence designing of …