The immune system and cancer have a complex relationship with the immune system
playing a dual role in tumor development. The effector cells of the immune system can …

Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …

Cells can detect and react to the biophysical properties of the extracellular environment
through integrin-based adhesion sites and adapt to the extracellular milieu in a process …

From the initial description of platelets in 1882, their propensity to aggregate and to
contribute to thrombosis was apparent. Indeed, excessive platelet aggregation is associated …

Cells sense and respond to the biochemical and physical properties of the extracellular
matrix (ECM) through adhesive structures that bridge the cell cytoskeleton and the …

Integrin adhesion receptors mediate the adhesion of blood cells, such as leukocytes, to
other cells, such as endothelial cells. Integrins also are critical for anchorage of …

Thrombo-inflammation describes the complex interplay between blood coagulation and
inflammation that plays a critical role in cardiovascular diseases. The third Maastricht …

Integrins are transmembrane receptors that mediate cell-cell and cell-extracellular matrix
adhesion. Although all integrins can undergo activation (affinity change for ligands), the …

The α L β 2 integrin LFA-1 is known to play a key role in T lymphocyte migration, which is
necessary to mount a local immune response, and is also the main driver of autoimmune …

Summary Canonical interleukin-2 (IL-2) signaling via the high-affinity CD25-containing IL-2
receptor-Janus kinase (JAK) 1, 3-signal transducer and activator of transcription 5 (STAT5) …