The potential use of bacteriophages as antibacterial agents against Klebsiella pneumoniae

O Gholizadeh, HEG Ghaleh, M Tat, R Ranjbar… - Virology Journal, 2024 - Springer
One of the most common bacteria that cause nosocomial infections is Klebsiella pneumonia
(K. pneumoniae), especially in patients who are very sick and admitted to the intensive care …

Differentiation of hypervirulent and classical Klebsiella pneumoniae with acquired drug resistance

TA Russo, CL Alvarado, CJ Davies, ZJ Drayer… - Mbio, 2024 - Am Soc Microbiol
Distinguishing hypervirulent (hvKp) from classical Klebsiella pneumoniae (cKp) strains is
important for clinical care, surveillance, and research. Some combinations of iucA, iroB, peg …

Animal models of Klebsiella pneumoniae mucosal infections

L Assoni, AJM Couto, B Vieira, B Milani… - Frontiers in …, 2024 - frontiersin.org
Klebsiella pneumoniae is among the most relevant pathogens worldwide, causing high
morbidity and mortality, which is worsened by the increasing rates of antibiotic resistance. It …

Heptavalent O-Antigen Bioconjugate Vaccine Exhibiting Differential Functional Antibody Responses Against Diverse Klebsiella pneumoniae Isolates

PL Wantuch, CJ Knoot, LS Robinson… - The Journal of …, 2024 - academic.oup.com
Klebsiella pneumoniae is the leading cause of neonatal sepsis and is increasingly difficult to
treat owing to antibiotic resistance. Vaccination represents a tractable approach to combat …

A novel antivirulent compound fluorothiazinone inhibits Klebsiella pneumoniae biofilm in vitro and suppresses model pneumonia

SV Tsarenko, NA Zigangirova, AV Soloveva… - The Journal of …, 2023 - nature.com
The problematic treatment of infections caused by multiple-resistant Klebsiella, especially in
ICU, is the leading cause of prolonged hospitalization and high mortality rates. The use of …

Diverse polysaccharide production and biofilm formation abilities of clinical Klebsiella pneumoniae

RL Beckman IV, E Cella, T Azarian… - npj Biofilms and …, 2024 - nature.com
Klebsiella pneumoniae infections have become a growing threat for human health. The lack
of understanding of the relationship between antibiotic resistance, mucoviscosity, and …

Anti-capsule human monoclonal antibodies protect against hypervirulent and pandrug-resistant Klebsiella pneumoniae

E Roscioli, VZ Galli Fonseca, SS Bosch, I Paciello… - bioRxiv, 2024 - biorxiv.org
The silent pandemic caused by antimicrobial resistance (AMR) requires innovative
therapeutic approaches. Human monoclonal antibodies (mAbs), which are among the most …

Polyamine-Mediated Sensitization of Klebsiella pneumoniae to Macrolides through a Dual Mode of Action

JME Adams, PB Moulding… - ACS Infectious …, 2024 - ACS Publications
Chemicals bacteria encounter at the infection site could shape their stress and antibiotic
responses; such effects are typically undetected under standard lab conditions. Polyamines …

Polyproline peptide targets Klebsiella pneumoniae polysaccharides to collapse biofilms

L De los Santos, RL Beckman, C DeBarro… - Cell Reports Physical …, 2024 - cell.com
Hypervirulent Klebsiella pneumoniae is known for its increased extracellular polysaccharide
production. Biofilm matrices of hypervirulent K. pneumoniae have increased polysaccharide …

Molecular characterization and virulence profile of Klebsiella pneumoniae and Klebsiella oxytoca isolated from ill cats and dogs in Portugal

J Castro, R Oliveira, L Fernandes, I Carvalho… - Veterinary …, 2024 - Elsevier
Klebsiella spp. are important pathogens of humans and companion animals such as cats
and dogs, capable of causing severe life-threatening diseases. The aim of this study was to …