How to study anxiety and depression in rodent models of chronic pain?
Mood disorders such as depression and anxiety are frequently observed in patients
suffering from chronic pain. Over time, different tests and models have been developed in …
suffering from chronic pain. Over time, different tests and models have been developed in …
Long noncoding RNA (lncRNA): a target in neuropathic pain
Introduction: Current treatments for neuropathic pain are limited in part due to the incomplete
understanding of its underlying mechanisms. Recent evidence reveals the dysregulated …
understanding of its underlying mechanisms. Recent evidence reveals the dysregulated …
[HTML][HTML] A nerve injury–specific long noncoding RNA promotes neuropathic pain by increasing Ccl2 expression
Maladaptive changes of nerve injury–associated genes in dorsal root ganglia (DRGs) are
critical for neuropathic pain genesis. Emerging evidence supports the role of long noncoding …
critical for neuropathic pain genesis. Emerging evidence supports the role of long noncoding …
Comparative transcriptome profiling of the human and mouse dorsal root ganglia: an RNA-seq–based resource for pain and sensory neuroscience research
2. Methods We performed RNA-seq for hDRG and integratively analyzed the transcriptome
by comparing it with publicly available human and mouse RNA-seq data sets (sources …
by comparing it with publicly available human and mouse RNA-seq data sets (sources …
[HTML][HTML] DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons
Nerve injury induces changes in gene transcription in dorsal root ganglion (DRG) neurons,
which may contribute to nerve injury-induced neuropathic pain. DNA methylation represses …
which may contribute to nerve injury-induced neuropathic pain. DNA methylation represses …
N6‐Methyladenosine Demethylase FTO Contributes to Neuropathic Pain by Stabilizing G9a Expression in Primary Sensory Neurons
Nerve injury‐induced change in gene expression in primary sensory neurons of dorsal root
ganglion (DRG) is critical for neuropathic pain genesis. N6‐methyladenosine (m6A) …
ganglion (DRG) is critical for neuropathic pain genesis. N6‐methyladenosine (m6A) …
Downregulation of a dorsal root ganglion‐specifically enriched long noncoding RNA is required for neuropathic pain by negatively regulating RALY‐triggered Ehmt2 …
Nerve injury‐induced maladaptive changes of gene expression in dorsal root ganglion
(DRG) neurons contribute to neuropathic pain. Long non‐coding RNAs (lncRNAs) are …
(DRG) neurons contribute to neuropathic pain. Long non‐coding RNAs (lncRNAs) are …
A dual noradrenergic mechanism for the relief of neuropathic allodynia by the antidepressant drugs duloxetine and amitriptyline
In addition to treating depression, antidepressant drugs are also a first-line treatment for
neuropathic pain, which is pain secondary to lesion or pathology of the nervous system …
neuropathic pain, which is pain secondary to lesion or pathology of the nervous system …
[HTML][HTML] The molecular fingerprint of dorsal root and trigeminal ganglion neurons
The dorsal root ganglia (DRG) and trigeminal ganglia (TG) are clusters of cell bodies of
highly specialized sensory neurons which are responsible for relaying information about our …
highly specialized sensory neurons which are responsible for relaying information about our …
Transcription factor EBF1 mitigates neuropathic pain by rescuing Kv1. 2 expression in primary sensory neurons
Y Liang, D Sharma, B Wang, H Wang, X Feng… - Translational …, 2024 - Elsevier
Nerve injury-induced alternations of gene expression in primary sensory neurons of the
dorsal root ganglion (DRG) are molecular basis of neuropathic pain genesis. Transcription …
dorsal root ganglion (DRG) are molecular basis of neuropathic pain genesis. Transcription …