Recent progress in continuous manufacturing of oral solid dosage forms
V Vanhoorne, C Vervaet - International Journal of Pharmaceutics, 2020 - Elsevier
Continuous drug product manufacturing is slowly being implemented in the pharmaceutical
industry. Although the benefits related to the quality and cost of continuous manufacturing …
industry. Although the benefits related to the quality and cost of continuous manufacturing …
Recent trends and future perspective of pharmaceutical wet granulation for better process understanding and product development
P Thapa, J Tripathi, SH Jeong - Powder Technology, 2019 - Elsevier
Current trends in pharmaceutical wet granulation have been shifted from traditional
approach to systematic and modern approaches, enabling the production of highly …
approach to systematic and modern approaches, enabling the production of highly …
Handbook of pharmaceutical granulation technology
DM Parikh - Drugs and the pharmaceutical sciences, 2005 - api.taylorfrancis.com
Since the Handbook of Pharmaceutical Granulation Technology, first and second editions,
were published, there have been rapid developments in the science of granulation, particle …
were published, there have been rapid developments in the science of granulation, particle …
A multivariate raw material property database to facilitate drug product development and enable in-silico design of pharmaceutical dry powder processes
B Van Snick, J Dhondt, K Pandelaere, J Bertels… - International journal of …, 2018 - Elsevier
In current study a holistic material characterization approach was proposed and an
extensive raw material property database was developed including a wide variety of APIs …
extensive raw material property database was developed including a wide variety of APIs …
Continuous twin screw granulation: A complex interplay between formulation properties, process settings and screw design
Due to the numerous advantages over batch manufacturing, continuous manufacturing
techniques such as twin screw wet granulation are rapidly gaining importance in …
techniques such as twin screw wet granulation are rapidly gaining importance in …
A multivariate approach to predict the volumetric and gravimetric feeding behavior of a low feed rate feeder based on raw material properties
In this study, the volumetric and gravimetric feeding behavior of 15 pharmaceutical powders
on a low feed rate feeder was correlated with their material properties through a multivariate …
on a low feed rate feeder was correlated with their material properties through a multivariate …
Continuous manufacturing via hot-melt extrusion and scale up: regulatory matters
M Maniruzzaman, A Nokhodchi - Drug discovery today, 2017 - Elsevier
Highlights•HME can be exploited in a broad range of applications for advanced drug
delivery.•Unique advantages to be utilized in a solvent free manufacturing platform.•A …
delivery.•Unique advantages to be utilized in a solvent free manufacturing platform.•A …
Continuous twin screw granulation: Influence of process and formulation variables on granule quality attributes of model formulations
In recent years, continuous manufacturing techniques, such as twin screw wet granulation,
have gained significant momentum. Due to the large diversity of the (model) formulations …
have gained significant momentum. Due to the large diversity of the (model) formulations …
Evaluation of the influence of material properties and process parameters on granule porosity in twin-screw wet granulation
M Peeters, AAB Jiménez, K Matsunami… - International Journal of …, 2023 - Elsevier
In recent years, continuous twin-screw wet granulation (TSWG) is gaining increasing interest
from the pharmaceutical industry. Despite the many publications on TSWG, only a limited …
from the pharmaceutical industry. Despite the many publications on TSWG, only a limited …
Optimization of critical quality attributes in continuous twin-screw wet granulation via design space validated with pilot scale experimental data
H Liu, SC Galbraith, B Ricart, C Stanton… - International Journal of …, 2017 - Elsevier
In this study, the influence of key process variables (screw speed, throughput and liquid to
solid (L/S) ratio) of a continuous twin screw wet granulation (TSWG) was investigated using …
solid (L/S) ratio) of a continuous twin screw wet granulation (TSWG) was investigated using …