Bioactive molecules against rheumatoid arthritis by suppressing pyroptosis

Q Zhou, T Li, G Fang, Y Pang, X Wang - Pharmaceuticals, 2023 - mdpi.com
Rheumatoid arthritis is an inflammatory disease, and pyroptosis is a form of death
associated with an inflammatory response. Pyroptosis, which occurs in synovial and …

Allicin: a promising modulator of apoptosis and survival signaling in cancer

S Bhuker, A Kaur, K Rajauria, HS Tuli, AK Saini… - Medical Oncology, 2024 - Springer
Abstract According to the World Health Organization, cancer is the foremost cause of
mortality globally. Various phytochemicals from natural sources have been extensively …

Deciphering the therapeutic potential of trimetazidine in rheumatoid arthritis via targeting mi-RNA128a, TLR4 signaling pathway, and adenosine-induced FADD …

E Omran, AR Alzahrani, SF Ezzat, G Ellithy… - Frontiers in …, 2024 - frontiersin.org
Rheumatoid arthritis (RA) is a debilitating autoimmune condition characterized by chronic
synovitis, joint damage, and inflammation, leading to impaired joint functionality. Existing RA …

Anti-ulcerative colitis effects of chemically characterized extracts from Calliandra haematocephala in acetic acid-induced ulcerative colitis

IU Rehman, M Saleem, SA Raza, S Bashir… - Frontiers in …, 2024 - frontiersin.org
Background: Ulcerative colitis is a chronic immune-mediated inflammatory bowel disease
that involves inflammation and ulcers of the colon and rectum. To date, no definite cure for …

Circ_0011058 alleviates RA pathology through the circ_0011058/miR-335-5p/CUL4B signal axis

X Wang, Q Xue, Q Duan, Z Sun, Y Wu, S Yang, P Xu… - …, 2024 - Taylor & Francis
Our previous study found that Cullin 4B (CUL4B) inhibited rheumatoid arthritis (RA)
pathology through glycogen synthase kinase-3beta (GSK3β)/canonical Wnt signalling …

Prepubertal Repeated Berberine Supplementation Enhances Cerebrocerebellar Functions by Modulating Neurochemical and Behavioural Changes in Wistar Rats

S Owumi, J Chimezie, M Otunla, B Oluwawibe… - Journal of Molecular …, 2024 - Springer
Antioxidant-rich supplementation plays an essential role in the function of mammals' central
nervous system. However, no research has documented the effect of berberine (BER) …

Chemical Analysis and Biological Activities of Various Parts of Securidaca longipedunculata From South Africa

K Shai, ZB Hassan, S Lebelo… - Natural Product …, 2024 - journals.sagepub.com
Objective The objective of our study was to investigate the chemical composition and the
biological activities of different parts of Securidaca longipedunculata from South Africa …

Asiatic acid inhibits rheumatoid arthritis fibroblast‐like synoviocyte growth through the Nrf2/HO‐1/NF‐κB signaling pathway

L Zhang, Z Liu, X Han, X Liu, Y Li - Chemical Biology & Drug …, 2024 - Wiley Online Library
Asiatic acid (AA) is generally recognized in the treatment of various diseases and has
significant advantages in the treatment of various inflammatory diseases. The treatment of …

Lupus and other autoimmune diseases: epidemiology in the population of African ancestry, and diagnostic and management challenges in Africa

M Essouma, JJ Noubiap - Journal of Allergy and Clinical Immunology …, 2024 - Elsevier
Autoimmune diseases are prevalent among people of African ancestry living outside of
Africa. However, the burden of autoimmune diseases in Africa is not well understood. This …

Ethnobotany and Phytochemical Composition of Alchornea Cordifolia in Abia State Nigeria

DN Enyiukwu, AC Amadioha… - International Journal of …, 2024 - dergipark.org.tr
Alchornea cordifolia is one of the medicinal plants used in treatment of several medical
challenges in Nigeria. The study was carried out to document the medicinal values of …