[HTML][HTML] Lipid nanoparticles for mRNA delivery
Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent
and treat various diseases. To function in vivo, mRNA requires safe, effective and stable …
and treat various diseases. To function in vivo, mRNA requires safe, effective and stable …
Nanomaterial delivery systems for mRNA vaccines
The recent success of mRNA vaccines in SARS-CoV-2 clinical trials is in part due to the
development of lipid nanoparticle delivery systems that not only efficiently express the …
development of lipid nanoparticle delivery systems that not only efficiently express the …
Toward nanotechnology-enabled approaches against the COVID-19 pandemic
The COVID-19 outbreak has fueled a global demand for effective diagnosis and treatment
as well as mitigation of the spread of infection, all through large-scale approaches such as …
as well as mitigation of the spread of infection, all through large-scale approaches such as …
[HTML][HTML] Delivering the messenger: advances in technologies for therapeutic mRNA delivery
mRNA has broad potential as a therapeutic. Current clinical efforts are focused on
vaccination, protein replacement therapies, and treatment of genetic diseases. The clinical …
vaccination, protein replacement therapies, and treatment of genetic diseases. The clinical …
The promise of mRNA vaccines: a biotech and industrial perspective
NAC Jackson, KE Kester, D Casimiro, S Gurunathan… - npj Vaccines, 2020 - nature.com
Abstract mRNA technologies have the potential to transform areas of medicine, including the
prophylaxis of infectious diseases. The advantages for vaccines range from the acceleration …
prophylaxis of infectious diseases. The advantages for vaccines range from the acceleration …
Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery
A new methodology termed selective organ targeting (SORT) was recently developed that
enables controllable delivery of nucleic acids to target tissues. SORT lipid nanoparticles …
enables controllable delivery of nucleic acids to target tissues. SORT lipid nanoparticles …
Peptide-encoding mRNA barcodes for the high-throughput in vivo screening of libraries of lipid nanoparticles for mRNA delivery
Developing safe and effective nanoparticles for the delivery of messenger RNA (mRNA) is
slow and expensive, partly due to the lack of predictive power of in vitro screening methods …
slow and expensive, partly due to the lack of predictive power of in vitro screening methods …
mRNA as a transformative technology for vaccine development to control infectious diseases
G Maruggi, C Zhang, J Li, JB Ulmer, D Yu - Molecular Therapy, 2019 - cell.com
In the last two decades, there has been growing interest in mRNA-based technology for the
development of prophylactic vaccines against infectious diseases. Technological …
development of prophylactic vaccines against infectious diseases. Technological …
The challenge and prospect of mRNA therapeutics landscape
Messenger RNA (mRNA)-based therapeutics hold the potential to cause a major revolution
in the pharmaceutical industry because they can be used for precise and individualized …
in the pharmaceutical industry because they can be used for precise and individualized …
The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis
F Zheng, J Chen, X Zhang, Z Wang, J Chen… - Nature …, 2021 - nature.com
Abstract Hypoxia-inducible factor-1 (HIF-1) is a master driver of glucose metabolism in
cancer cells. Here, we demonstrate that a HIF-1α anti-sense lncRNA, HIFAL, is essential for …
cancer cells. Here, we demonstrate that a HIF-1α anti-sense lncRNA, HIFAL, is essential for …