The roles and regulatory mechanisms of TGF-β and BMP signaling in bone and cartilage development, homeostasis and disease
Transforming growth factor-βs (TGF-βs) and bone morphometric proteins (BMPs) belong to
the TGF-β superfamily and perform essential functions during osteoblast and chondrocyte …
the TGF-β superfamily and perform essential functions during osteoblast and chondrocyte …
Biological functions of fucose in mammals
M Schneider, E Al-Shareffi, RS Haltiwanger - Glycobiology, 2017 - academic.oup.com
Fucose is a 6-deoxy hexose in the l-configuration found in a large variety of different
organisms. In mammals, fucose is incorporated into N-glycans, O-glycans and glycolipids by …
organisms. In mammals, fucose is incorporated into N-glycans, O-glycans and glycolipids by …
ADAMTS proteins in human disorders
TJ Mead, SS Apte - Matrix Biology, 2018 - Elsevier
ADAMTS proteins are a superfamily of 26 secreted molecules comprising two related, but
distinct families. ADAMTS proteases are zinc metalloendopeptidases, most of whose …
distinct families. ADAMTS proteases are zinc metalloendopeptidases, most of whose …
[HTML][HTML] Elastic fibers during aging and disease
A Heinz - Ageing research reviews, 2021 - Elsevier
Elastic fibers are essential constituents of the extracellular matrix of higher vertebrates and
endow several tissues and organs including lungs, skin and blood vessels with elasticity …
endow several tissues and organs including lungs, skin and blood vessels with elasticity …
Dynamic interstitial cell response during myocardial infarction predicts resilience to rupture in genetically diverse mice
Cardiac ischemia leads to the loss of myocardial tissue and the activation of a repair process
that culminates in the formation of a scar whose structural characteristics dictate propensity …
that culminates in the formation of a scar whose structural characteristics dictate propensity …
FBN1: The disease-causing gene for Marfan syndrome and other genetic disorders
LY Sakai, DR Keene, M Renard, J De Backer - Gene, 2016 - Elsevier
FBN1 encodes the gene for fibrillin-1, a structural macromolecule that polymerizes into
microfibrils. Fibrillin microfibrils are morphologically distinctive fibrils, present in all …
microfibrils. Fibrillin microfibrils are morphologically distinctive fibrils, present in all …
A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms
SS Apte - Journal of Biological Chemistry, 2009 - ASBMB
Together with seven ADAMTS-like proteins, the 19 mammalian ADAMTS proteases
constitute a superfamily. ADAMTS proteases are secreted zinc metalloproteases whose …
constitute a superfamily. ADAMTS proteases are secreted zinc metalloproteases whose …
[HTML][HTML] Fibrillin microfibrils and elastic fibre proteins: Functional interactions and extracellular regulation of growth factors
Fibrillin microfibrils are extensible polymers that endow connective tissues with long-range
elasticity and have widespread distributions in both elastic and non-elastic tissues. They act …
elasticity and have widespread distributions in both elastic and non-elastic tissues. They act …
Protein O-fucosylation: structure and function
BC Holdener, RS Haltiwanger - Current opinion in structural biology, 2019 - Elsevier
Highlights•Protein O-fucosyltransferases 1 and 2 (POFUT1 and POFUT2) are ER-localized
and modify EGF repeats and TSRs.•Both POFUT1 and POFUT2 are exquisitely selective for …
and modify EGF repeats and TSRs.•Both POFUT1 and POFUT2 are exquisitely selective for …
TGF-β and BMP signaling pathways in skeletal dysplasia with short and tall stature
A Costantini, A Guasto… - Annual Review of …, 2023 - annualreviews.org
The transforming growth factor β (TGF-β) and bone morphogenetic protein (BMP) signaling
pathways play a pivotal role in bone development and skeletal health. More than 30 different …
pathways play a pivotal role in bone development and skeletal health. More than 30 different …