The gene known as neu, erbB-2, or HER-2 is among those most frequently altered in human
cancer, neu was first identified as a transforming gene activated in chemically induced rat …

Five structural features in mRNAs have been found to contribute to the fidelity and efficiency
of initiation by eukaryotic ribosomes. Scrutiny of vertebrate cDNA sequences in light of these …

We sought to determine whether human corneal epithelial cells and stromal fibroblasts
synthesize messenger RNAs (mRNA) coding for epidermal growth factor (EGF), EGF …

Abstract Cao, N., Li, S., Wang, Z., Ahmed, KM, Degnan, ME, Fan, M., Dynlacht, JR and Li, JJ
NF-κB-Mediated HER2 Overexpression in Radiation-Adaptive Resistance. Radiat. Res. 171 …

Cloned sequences encoding a truncated form of the HER2 receptor were obtained from
cDNA libraries derived from two HER2-overexpressing human breast cancer cell lines, BT …

Simian virus 40-based plasmids that direct the synthesis of preproinsulin in cultured monkey
cells were used to study the effects of mRNA structure on translational efficiency …

HER-2/neu (erbB-2) encodes an 185-kDa orphan receptor tyrosine kinase that is
constitutively active as a dimer and displays potent oncogenic activity when overexpressed …

Because HER-2/neu overexpression is important in cancer development, we looked for a
method of suppressing the cell transformation mediated by HER-2/neu overexpression. We …

More than 50% of breast cancers are currently defined as “Human epidermal growth factor
receptor 2 (HER2) low breast cancer (BC)”, with HER2 immunohistochemistry (IHC) scores …

The c‐erbB‐2 receptor tyrosine kinase proto‐oncogene product is overexpressed in 20‐
30% of breast carcinomas and this has been shown to correlate with poor prognosis …