Protein disulphide isomerase inhibition as a potential cancer therapeutic strategy
LE Powell, PA Foster - Cancer medicine, 2021 - Wiley Online Library
The protein disulphide isomerase (PDI) gene family is a large, diverse group of enzymes
recognised for their roles in disulphide bond formation within the endoplasmic reticulum …
recognised for their roles in disulphide bond formation within the endoplasmic reticulum …
Targeting the redox landscape in cancer therapy
D Narayanan, S Ma, D Özcelik - Cancers, 2020 - mdpi.com
Reactive oxygen species (ROS) are produced predominantly by the mitochondrial electron
transport chain and by NADPH oxidases in peroxisomes and in the endoplasmic reticulum …
transport chain and by NADPH oxidases in peroxisomes and in the endoplasmic reticulum …
Discovery and mechanistic elucidation of a class of protein disulfide isomerase inhibitors for the treatment of glioblastoma
Protein disulfide isomerase (PDI) is overexpressed in glioblastoma, the most aggressive
form of brain cancer, and folds nascent proteins responsible for the progression and spread …
form of brain cancer, and folds nascent proteins responsible for the progression and spread …
Roles of protein disulfide isomerase in breast cancer
Simple Summary Triple-negative breast cancer (TNBC) is the most aggressive subtype of
breast cancer and has a poor prognosis and higher recurrence rate due to ineffective …
breast cancer and has a poor prognosis and higher recurrence rate due to ineffective …
ERO1-PDI redox signaling in health and disease
Significance: Protein disulfide isomerase (PDI) and endoplasmic reticulum oxidoreductase 1
(ERO1) are crucial for oxidative protein folding in the endoplasmic reticulum (ER). These …
(ERO1) are crucial for oxidative protein folding in the endoplasmic reticulum (ER). These …
Biomechanical thrombosis: the dark side of force and dawn of mechano-medicine
Arterial thrombosis is in part contributed by excessive platelet aggregation, which can lead
to blood clotting and subsequent heart attack and stroke. Platelets are sensitive to the …
to blood clotting and subsequent heart attack and stroke. Platelets are sensitive to the …
Revisiting the mechanistic basis of the French Paradox: Red wine inhibits the activity of protein disulfide isomerase in vitro
CN Galinski, JI Zwicker, DR Kennedy - Thrombosis research, 2016 - Elsevier
Introduction Although epidemiologic evidence points to cardioprotective activity of red wine,
the mechanistic basis for antithrombotic activity has not been established. Quercetin and …
the mechanistic basis for antithrombotic activity has not been established. Quercetin and …
Discovery of 5-Hydroxy-1, 4-naphthoquinone (Juglone) Derivatives as Dual Effective Agents Targeting Platelet-Cancer Interplay through Protein Disulfide Isomerase …
In this study, a series of 2-and/or 3-substituted juglone derivatives were designed and
synthesized. Among them, 9, 18, 22, 30, and 31 showed stronger inhibition activity against …
synthesized. Among them, 9, 18, 22, 30, and 31 showed stronger inhibition activity against …
[HTML][HTML] Targeting thiol isomerase activity with zafirlukast to treat ovarian cancer from the bench to clinic
JA Gelzinis, MK Szahaj, RH Bekendam… - … : official publication of …, 2023 - ncbi.nlm.nih.gov
Thiol isomerases, including PDI, ERp57, ERp5, and ERp72 play important and distinct roles
in cancer progression, cancer cell signaling, and metastasis. We recently discovered that …
in cancer progression, cancer cell signaling, and metastasis. We recently discovered that …
Protein disulfide isomerases regulate IgE-mediated mast cell responses and their inhibition confers protective effects during food allergy
D Krajewski, SH Polukort, J Gelzinis, J Rovatti… - Frontiers in …, 2020 - frontiersin.org
The thiol isomerase, protein disulfide isomerase (PDI), plays important intracellular roles
during protein folding, maintaining cellular function and viability. Recent studies suggest …
during protein folding, maintaining cellular function and viability. Recent studies suggest …