Coumarins are found in higher plants like Rutaceae and Umbelliferae and essential oils of
cinnamon bark, cassia leaf, and lavender oil. Coumarin compounds show different …

Abstract Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional enzyme involved
in the base excision repair (BER) pathway, which repairs oxidative base damage caused by …

Drug resistance is a major impediment for cancer treatment, to overcome it we designed and
synthesized sixteen coumarins bearing hydrazide–hydrazone moiety and evaluated them …

Abstract Treatment of cancer has been limited by the poor efficacy and toxicity profiles of
available drugs. There is a growing demand to develop alternative approaches to combat …

Osteoarthritis (OA) is a common joint disease that takes joint degeneration or aging as its
pathological basis, and joint swelling, pain or dysfunction as its main clinical manifestations …

Introduction: Caspase-9 is the apoptotic initiator protease of the intrinsic or mitochondrial
apoptotic pathway, which is activated at multi-protein activation platforms. Its activation is …

Here, we assessed and compared the anticancer efficacy and associated mechanisms of
silymarin and silibinin in human prostate cancer (PCA) PC3 cells; silymarin is comprised of …

Angelica species have been traditionally used for their medicinal properties. Recent studies
have suggested their potential use as anticancer agents, making them an area of interest for …

Usnic acid (UA) is a secondary metabolite abundantly found in lichens. Some studies have
shown the anticancer potential of UA; however, its efficacy and associated mechanisms are …

Abstract Acacetin (5, 7-dihydroxy-4′-methoxyflavone), a flavonoid compound, has anti-
peroxidative and anti-inflammatory effects. The effect of acacetin on antimetastasis in human …