Because of their well-recognized immunomodulatory properties, mesenchymal stromal cells
(MSCs) represent an attractive cell population for therapeutic purposes. In particular, there is …

Psychological distress has long been suspected to influence cancer incidence and mortality.
It remains largely unknown whether and how stress affects the efficacy of anticancer …

Glucocorticoid-induced leucine zipper (GILZ) is a protein with multiple biological roles that is
upregulated by glucocorticoids (GCs) in both immune and non-immune cells. Importantly …

Numerous biological systems oscillate over time or space. Despite these oscillators'
importance, data from an oscillatory system is problematic for existing methods of …

Essentials• M1/M2 imbalance is involved in many autoimmune diseases, and could be
restored.• The expressions and functions of M1 and M2 were investigated in an in vitro …

Glucocorticoids (GC), synthesized by the 11β-hydroxylase (Cyp11b1), control excessive
inflammation through immunosuppressive actions. The skin was proposed to regulate …

Immunosuppressive drugs in clinical transplantation are necessary to inhibit the immune
response to donor antigens. Although they are effective in controlling acute rejection, they …

The ability of dendritic cells (DCs) to trigger tolerance or immunity is dictated by the context
in which an antigen is encountered. A large body of evidence indicates that antigen …

Endogenous levels of glucocorticoids rise during pregnancy to warrant development and
maturation of the fetal organs close to birth. However, during most of the gestation, the fetus …

Chronic graft-versus-host disease (cGVHD) is a major cause of late mortality following
allogeneic bone marrow transplantation (BMT) and is characterized by tissue fibrosis …