Osteoporosis (OP) is the most prevalent metabolic bone disease, characterized by the low
bone mass and microarchitectural deterioration of bone tissue. Glucocorticoid (GC) clinically …

Secondary osteoporosis is commonly caused by long-term intake of glucocorticoids (GCs),
such as dexamethasone (DEX). Diosmin, a natural substance with potent antioxidant and …

Obesity and osteoporosis are two prevalent conditions that are becoming increasingly
common worldwide, primarily due to aging populations, imbalanced energy intake, and …

In our previous study, a novel BMP2 secretagogue was synthesized belonging to a class of
galloyl conjugates of flavanones, with remarkable osteogenic potential that promoted bone …

Osteoporosis, a systemic bone disease that is characterized by a reduction in bone mass
and destruction of bone microstructure, is becoming a serious problem worldwide. Bone …

Mutations in SOST can lead to various monogenic bone diseases. Its paralog, SOSTDC1,
shares 55% protein sequence homology and belongs to the BMP antagonist class …

Aims Postmenopausal osteoporosis is one of the world's biggest yet unnoticed health
issues. After ovariectomy, declined estrogen level significantly contributes to the elevation of …

Chondrocytes are the only resident cell types that form the extracellular matrix of cartilage.
Inflammation alters the anabolic and catabolic regulation of chondrocytes, resulting in the …

In search of novel osteogenic entities, a series of twenty-seven quinazolinone-benzopyran-
indole hybrids were designed and synthesized using molecular hybridization approach. All …

Osteoporosis is induced by an imbalance between osteogenesis and bone resorption, and
is treated with osteogenic drugs and/or resorption inhibitors. Resorption inhibitors, such as …