Regulation and functions of non-m6A mRNA modifications
Nucleobase modifications are prevalent in eukaryotic mRNA and their discovery has
resulted in the emergence of epitranscriptomics as a research field. The most abundant …
resulted in the emergence of epitranscriptomics as a research field. The most abundant …
The roles and implications of RNA m6A modification in cancer
Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
Exclusion of m6A from splice-site proximal regions by the exon junction complex dictates m6A topologies and mRNA stability
Summary N6-methyladenosine (m6A), a widespread destabilizing mark on mRNA, is non-
uniformly distributed across the transcriptome, yet the basis for its selective deposition is …
uniformly distributed across the transcriptome, yet the basis for its selective deposition is …
N6-methyladenosine-mediated gene regulation and therapeutic implications
Abstract N6-methyladenosine (m 6 A) RNA methylation is the most abundant form of mRNA
modification in eukaryotes and is at the front line of biological and biomedical research. This …
modification in eukaryotes and is at the front line of biological and biomedical research. This …
Mapping epigenetic modifications by sequencing technologies
The “epigenetics” concept was first described in 1942. Thus far, chemical modifications on
histones, DNA, and RNA have emerged as three important building blocks of epigenetic …
histones, DNA, and RNA have emerged as three important building blocks of epigenetic …
Simultaneous nanopore profiling of mRNA m6A and pseudouridine reveals translation coordination
Abstract N6-methyladenosine (m6A) and pseudouridine (Ψ) are the two most abundant
modifications in mammalian messenger RNA, but the coordination of their biological …
modifications in mammalian messenger RNA, but the coordination of their biological …
Emerging roles of RNA methylation in development
MK Wang, CC Gao, YG Yang - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus More than 170 different types of chemical modifications have been identified on
diverse types of RNA, collectively known as the epitranscriptome. Among them, N 6 …
diverse types of RNA, collectively known as the epitranscriptome. Among them, N 6 …
Epitranscriptomics in metabolic disease
Y Matsumura, FY Wei, J Sakai - Nature Metabolism, 2023 - nature.com
While epigenetic modifications of DNA and histones play main roles in gene transcription
regulation, recently discovered post-transcriptional RNA modifications, known as …
regulation, recently discovered post-transcriptional RNA modifications, known as …
Single-nucleus multiomic mapping of m6A methylomes and transcriptomes in native populations of cells with sn-m6A-CT
Summary N 6-methyladenosine (m 6 A) RNA modification plays important roles in the
governance of gene expression and is temporally regulated in different cell states. In …
governance of gene expression and is temporally regulated in different cell states. In …
Quantifying m6A and Ψ Modifications in the Transcriptome via Chemical-Assisted Approaches
Conspectus Since the discovery of the first chemically modified RNA nucleotide in 1951,
more than 170 types of chemical modifications have been characterized in RNA so far …
more than 170 types of chemical modifications have been characterized in RNA so far …