Primary tumors are responsible for 10% of cancer deaths. In most cases, the main cause of
mortality is the formation of metastases. Accumulating evidence suggests that a …

Normal stem cells and cancer stem cells (CSCs) share similar properties, in that both have
the capacity to self-renew and differentiate into multiple cell types. In both the normal stem …

Background Recently, a variety of clinical trials have shown that apatinib, a small-molecule
anti-angiogenic drug, exerts promising inhibitory effects on multiple solid tumors, including …

Background The cancer stem cell theory hypothesizes that cancers are perpetuated by
cancer stem cells (CSC) or tumor initiating cells (TIC) possessing self-renewal and other …

Introduction Inherent and acquired cisplatin resistance reduces the effectiveness of this
agent in the management of non-small cell lung cancer (NSCLC). Understanding the …

Lung cancer is the leading cause of cancer-related death in men and women in the United
States, accounting for approximately 28% of total cancer deaths in 2010 despite comprising …

EXECUTIVE SUMMARY The University of Vermont College of Medicine and the Vermont
Lung Center, with support of the National Heart, Lung, and Blood Institute (NHLBI), the …

The mechanistic target of rapamycin (mTOR), via its two distinct multiprotein complexes,
mTORC1, and mTORC2, plays a central role in the regulation of cellular growth, metabolism …

Epigenetic reprogramming plays a pivotal role during embryogenesis, including both
covalent and non-covalent modifications to chromatin. In this study, we investigated the role …

Chemotherapy in cancer patients is still not satisfactory because of drug resistance. The
main mechanism of drug resistance results from the ability of cancer cells to actively expel …