Stress and cancer: mechanisms, significance and future directions

A Eckerling, I Ricon-Becker, L Sorski… - Nature Reviews …, 2021 - nature.com
The notion that stress and cancer are interlinked has dominated lay discourse for decades.
More recent animal studies indicate that stress can substantially facilitate cancer …

Aspects of the tumor microenvironment involved in immune resistance and drug resistance

K Khalaf, D Hana, JTT Chou, C Singh… - Frontiers in …, 2021 - frontiersin.org
The tumor microenvironment (TME) is a complex and ever-changing “rogue organ”
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …

The impact of psychosocial stress and stress management on immune responses in patients with cancer

MH Antoni, FS Dhabhar - Cancer, 2019 - Wiley Online Library
The range of psychosocial stress factors/processes (eg, chronic stress, distress states,
coping, social adversity) were reviewed as they relate to immune variables in cancer along …

Tumor microenvironment of hepatocellular carcinoma: challenges and opportunities for new treatment options

Z Sas, E Cendrowicz, I Weinhäuser… - International Journal of …, 2022 - mdpi.com
The prevalence of liver cancer is constantly rising, with increasing incidence and mortality in
Europe and the USA in recent decades. Among the different subtypes of liver cancers …

Tumor innervation: peripheral nerves take control of the tumor microenvironment

SM Gysler, R Drapkin - The Journal of clinical investigation, 2021 - Am Soc Clin Investig
In recent decades, cancer research has expanded exponentially beyond the study of
abnormally dividing cells to include complex and extensive heterotypic interactions between …

Exploiting the critical perioperative period to improve long-term cancer outcomes

M Horowitz, E Neeman, E Sharon… - Nature reviews Clinical …, 2015 - nature.com
Evidence suggests that the perioperative period and the excision of the primary tumour can
promote the development of metastases—the main cause of cancer-related mortality. This …

The sympathetic nervous system induces a metastatic switch in primary breast cancer

EK Sloan, SJ Priceman, BF Cox, S Yu, MA Pimentel… - Cancer research, 2010 - AACR
Metastasis to distant tissues is the chief driver of breast cancer–related mortality, but little is
known about the systemic physiologic dynamics that regulate this process. To investigate …

Perioperative COX-2 and β-adrenergic blockade improves metastatic biomarkers in breast cancer patients in a phase-II randomized trial

L Shaashua, M Shabat-Simon, R Haldar… - Clinical Cancer …, 2017 - AACR
Purpose: Translational studies suggest that excess perioperative release of catecholamines
and prostaglandins may facilitate metastasis and reduce disease-free survival. This trial …

Epidural anesthesia–analgesia and recurrence-free survival after lung cancer surgery: a randomized trial

ZZ Xu, HJ Li, MH Li, SM Huang, X Li, QH Liu… - …, 2021 - ingentaconnect.com
Background: Regional anesthesia and analgesia reduce the stress response to surgery and
decrease the need for volatile anesthesia and opioids, thereby preserving cancer-specific …

The influence of bio-behavioural factors on tumour biology: pathways and mechanisms

MH Antoni, SK Lutgendorf, SW Cole, FS Dhabhar… - Nature reviews …, 2006 - nature.com
Epidemiological studies indicate that stress, chronic depression and lack of social support
might serve as risk factors for cancer development and progression. Recent cellular and …