Electrochemical dearomative spirocyclization

N Li, Z Shi, WZ Wang, Y Yuan… - Chemistry–An Asian …, 2023 - Wiley Online Library
Electrochemical dearomative spirocyclization serves as a green and sustainable approach
to convert the flat, two‐dimension aromatic feedstock into the value‐added three‐dimension …

Electrochemical electrophilic bromination/spirocyclization of N-benzyl-acrylamides to brominated 2-azaspiro [4.5] decanes

Z Zhang, ZW Hou, H Chen, P Li, L Wang - Green Chemistry, 2023 - pubs.rsc.org
An electrochemical electrophilic bromination/spirocyclization of N-benzyl-acrylamides with 2-
bromoethan-1-ol as the brominating reagent has been developed. The paired electrolysis …

Silver-Enabled Dearomative Trifluoromethoxylation of Indoles

Z Deng, L Meng, X Bing, S Niu, X Zhang… - Journal of the …, 2024 - ACS Publications
The only known method for the dearomative trifluoromethoxylation of indoles is preliminary,
with only one substrate successfully undergoing the reaction. In this study, we not only …

Research Advances in Electrochemical Synthesis of Spirocyclic Skeleton Compounds

Q Wang, HF Liu, SY Ren, MX He, YM Pan - Synthesis, 2023 - thieme-connect.com
Spirocyclic compounds have attracted the interest of synthetic chemists because of their
unique ring systems and utility in drug discovery. Many natural compounds containing …

Cp2Fe Mediated Electrochemical Synthesis of Phosphonylated Spirocyclic Indolines via Dearomatization of Indoles

K Mo, X Zhou, J Wang, J Wu, Y Zhao - Organic Letters, 2023 - ACS Publications
A general and robust strategy for the synthesis of phosphonylated spirocyclic indolines has
been developed through Cp2Fe-catalyzed electrochemical dearomaztizaion of indoles …

Electrosynthesis of spiro-indolenines via dearomative arylation of indoles in batch and continuous flow

W Zhao, Y Lu, Y Qiao, X Yin, C Liu, Z Fang, J Zhu… - Organic …, 2023 - ACS Publications
An electrosynthesis of spiro-indolenines in batch and continuous flow was achieved through
dearomative arylation of indoles with good functional group compatibility. User-friendly …

Electrochemical Dearomative Spirocyclization of N-Acyl Thiophene-2-sulfonamides

Z Shi, WZ Wang, N Li, Y Yuan, KY Ye - Organic Letters, 2022 - ACS Publications
The Friedel–Crafts type alkylation of C2-tethered thiophenes has been reported to be
nonregioselective. Taking advantage of the highly regioselective 5-exo-trig spirocyclization …

Electrochemical Multicomponent Cascade Radical Process Enabling Synthesis of Iodomethyl Spiropyrrolidinyl‐Oxindoles

J He, H Mei, J Escorihuela, J Han - Chinese Journal of …, 2024 - Wiley Online Library
Comprehensive Summary A novel electrochemical multicomponent cascade reaction of
indole‐tethered alkenes with CF3SO2Na and n‐Bu4NI has been developed, which enables …

Electrooxidative α-hydroxymethylation of ketones with dimethylformamide as the carbon source

JM Zheng, YF Li, YX Pan, XD Hu, XX Ye, RH Li - Green Chemistry, 2023 - pubs.rsc.org
An environmentally benign electrochemical approach has been developed for the α-
hydroxymethylation of ketones using N, N-dimethylformamide as the carbon source for the …

Metal-free electrochemical oxidative difluoroethylation/cyclization of olefinic amides to construct difluoroethylated azaheterocycles

Y Tian, L Zheng, Z Wang, Z Li, W Fu - The Journal of Organic …, 2023 - ACS Publications
A new strategy of electrochemical oxidative difluoroethylation to generate difluoroethyl
radical with sodium difluoroethylsulfinate (DFES-Na) has been reported for the first time. The …