Background The degree of efficacy, safety, quality, and certainty of meta-analytic evidence of
biological non-pharmacological treatments in mental disorders is unclear. Methods We …

Antipsychotic drugs are the mainstay in the treatment of schizophrenia. However, one-third
of patients do not show adequate improvement in positive symptoms with non-clozapine …

Negative symptoms of schizophrenia remain a major therapeutic challenge. The progress in
the conceptualization and assessment is not yet fully reflected by treatment research …

A group of European experts was commissioned to establish guidelines on the therapeutic
use of repetitive transcranial magnetic stimulation (rTMS) from evidence published up until …

The core symptoms of different dementia subtypes are the behavioral and psychological
symptoms of dementia (BPSD) and its neuropsychiatric symptoms (NPS). BPSD symptoms …

Mental health disorders and substance use disorders are a leading cause of morbidity and
mortality worldwide, and one of the most important challenges for public health systems …

Importance Negative symptoms represent a substantial burden in schizophrenia. Although
preliminary studies have suggested that transcranial direct current stimulation (tDCS) is …

Several trials have shown preliminary evidence for the efficacy of transcranial magnetic
stimulation (TMS) as a treatment for negative symptoms in schizophrenia. Here, we …

Vagal nerve stimulation (VNS) is known as an effective method of treatment in a number of
neurological disorders. The low risk of side effects also makes it useful in clinical trials in …

Objective Negative symptoms of schizophrenia are substantially disabling and treatment
resistant. Novel treatments like repetitive transcranial magnetic stimulation (TMS) need to be …