Strategies to counteract or prevent emerging drug resistance are crucial for the design of
next-generation antimalarials. In the past, resistant parasites were generally identified …

Conspectus Over the last century, malaria deaths have decreased by more than 85%.
Nonetheless, there were 405 000 deaths in 2018, mostly resulting from Plasmodium …

Drug-resistant Plasmodium falciparum parasites have swept across Southeast Asia and now
threaten Africa. By implementing a P. falciparum genetic cross using humanized mice, we …

The emergence and spread of Plasmodium falciparum resistance to first-line antimalarials
creates an imperative to identify and develop potent preclinical candidates with distinct …

We report detailed susceptibility profiling of asexual blood stages of the malaria parasite
Plasmodium falciparum to clinical and experimental antimalarials, combined with …

CRISPR/Cas9 approaches are revolutionizing our ability to perform functional genomics
across a wide range of organisms, including the Plasmodium parasites that cause malaria …

Membrane transport proteins, also known as transporters, control the movement of ions,
nutrients, metabolites, and waste products across the membranes of a cell and are central to …

Novel carbon microsphere-supported metallic copper nanoparticles (Cu-NP/C) were
synthesized using a low-cost and facile method based on carbonising a styrene-based …

Oxo-hexahydroquinoline (5-oxo-HHQ) represents a biologically attractive fused heterocyclic
core. Various synthetic analogs of 5-oxo-HHQ have been synthesized and assessed for …

Abstract Ethnopharmacological relevance Having identified Annickia affinis as the most
potent antiplasmodial plant constituent in a hepta-herbal Agbo-iba (HHA) formula commonly …