Translating ribosomes slow down or completely stall when they encounter obstacles on
mRNAs. Such events can lead to ribosomes colliding with each other and forming …

In vitro-transcribed (IVT) mRNAs are modalities that can combat human disease, exemplified
by their use as vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

The recent discovery that collision of ribosomes triggers quality control and stress responses
in eukaryotes has shifted the perspective of the field. Collided eukaryotic ribosomes adopt a …

Messenger RNAs (mRNAs) encode information in both their primary sequence and their
higher order structure. The independent contributions of factors like codon usage and …

The ribosome-associated protein quality control (RQC) system that resolves stalled
translation events is activated when ribosomes collide and form disome, trisome, or higher …

The Gcn pathway is conserved in all eukaryotes, including mammals such as humans,
where it is a crucial part of the integrated stress response (ISR). Gcn1 serves as an essential …

Ribosome rescue pathways recycle stalled ribosomes and target problematic mRNAs and
aborted proteins for degradation,. In bacteria, it remains unclear how rescue pathways …

Translation of aberrant mRNAs can cause ribosomes to stall, leading to collisions with
trailing ribosomes. Collided ribosomes are specifically recognised by ZNF598 to initiate …

Inhibitory codon pairs and poly (A) tracts within the translated mRNA cause ribosome
stalling and reduce protein output. The molecular mechanisms that drive these stalling …

CGG repeat expansions in the FMR1 5'UTR cause the neurodegenerative disease Fragile X-
associated tremor/ataxia syndrome (FXTAS). These repeats form stable RNA secondary …