Hippo effectors YAP and TAZ control cell fate and survival through various mechanisms,
including transcriptional regulation of key genes. However, much of this research has been …

Animal tissues comprise diverse cell types. However, the mechanisms controlling the
number of each cell type within tissue compartments remain poorly understood. Here, we …

The Hippo pathway is a central regulator of tissue growth that has been widely studied in
mammalian organ development, regeneration, and cancer biology. Although previous …

Advancing the technologies for cellular reprogramming with high efficiency has significant
impact on regenerative therapy, disease modeling, and drug discovery. Biophysical cues …

Induced pluripotent stem cells (iPSCs) have wide applications in disease modeling,
personalized medicine, and tissue engineering. The generation of iPSCs from somatic cells …

Cells can secrete molecules that help each other's replication. In cell cultures, chemical
signals might diffuse only within a cell colony or between colonies. A chemical signal's …

Cell reprogramming can either refer to a direct conversion of a specialized cell into another
or to a reversal of a somatic cell into an induced pluripotent stem cell (iPSC). It implies a …

Cellular reprogramming drives cells from one stable identity to a new cell fate. By generating
a diversity of previously inaccessible cell types from diverse genetic backgrounds, cellular …

Tissue regeneration after injury involves the dedifferentiation of somatic cells, a natural
adaptive reprogramming that leads to the emergence of injury-responsive cells with fetal-like …

Human cellular reprogramming to induced pluripotency is still an inefficient process, which
has hindered studying the role of critical intermediate stages. Here we take advantage of …