[HTML][HTML] Mucins in intestinal mucosal defense and inflammation: learning from clinical and experimental studies
Throughout the gastrointestinal (GI) tract, a distinct mucus layer composed of highly
glycosylated proteins called mucins plays an essential role in providing lubrication for the …
glycosylated proteins called mucins plays an essential role in providing lubrication for the …
Clostridioides difficile toxins: mechanisms of action and antitoxin therapeutics
Clostridioides difficile is a Gram-positive anaerobe that can cause a spectrum of disorders
that range in severity from mild diarrhoea to fulminant colitis and/or death. The bacterium …
that range in severity from mild diarrhoea to fulminant colitis and/or death. The bacterium …
Understanding the mechanisms and drivers of antimicrobial resistance
To combat the threat to human health and biosecurity from antimicrobial resistance, an
understanding of its mechanisms and drivers is needed. Emergence of antimicrobial …
understanding of its mechanisms and drivers is needed. Emergence of antimicrobial …
Culturing of 'unculturable'human microbiota reveals novel taxa and extensive sporulation
Our intestinal microbiota harbours a diverse bacterial community required for our health,
sustenance and wellbeing,. Intestinal colonization begins at birth and climaxes with the …
sustenance and wellbeing,. Intestinal colonization begins at birth and climaxes with the …
Discovery of semi-and fully-synthetic carbohydrate vaccines against bacterial infections using a medicinal chemistry approach: focus review
PH Seeberger - Chemical Reviews, 2021 - ACS Publications
The glycocalyx, a thick layer of carbohydrates, surrounds the cell wall of most bacterial and
parasitic pathogens. Recognition of these unique glycans by the human immune system …
parasitic pathogens. Recognition of these unique glycans by the human immune system …
Clostridium difficile infection
Infection of the colon with the Gram-positive bacterium Clostridium difficile is potentially life
threatening, especially in elderly people and in patients who have dysbiosis of the gut …
threatening, especially in elderly people and in patients who have dysbiosis of the gut …
Clostridium difficile Infection
DA Leffler, JT Lamont - New England Journal of Medicine, 2015 - Mass Medical Soc
This article reviews the pathogenesis, epidemiology, diagnosis, and treatment of this
nosocomial and potentially fatal infectious diarrhea, as well as the associated risk factors …
nosocomial and potentially fatal infectious diarrhea, as well as the associated risk factors …
Dietary trehalose enhances virulence of epidemic Clostridium difficile
Clostridium difficile disease has recently increased to become a dominant nosocomial
pathogen in North America and Europe, although little is known about what has driven this …
pathogen in North America and Europe, although little is known about what has driven this …
Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success
LS Redgrave, SB Sutton, MA Webber… - Trends in microbiology, 2014 - cell.com
Quinolone and fluoroquinolone antibiotics are potent, broad-spectrum agents commonly
used to treat a range of infections. Resistance to these agents is multifactorial and can be via …
used to treat a range of infections. Resistance to these agents is multifactorial and can be via …
The role of toxins in Clostridium difficile infection
R Chandrasekaran, DB Lacy - FEMS microbiology reviews, 2017 - academic.oup.com
Clostridium difficile is a bacterial pathogen that is the leading cause of nosocomial antibiotic-
associated diarrhea and pseudomembranous colitis worldwide. The incidence, severity …
associated diarrhea and pseudomembranous colitis worldwide. The incidence, severity …