VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is a
monogenic disease of adulthood caused by somatic mutations in UBA1 in hematopoietic …

In primary Sjögren syndrome (pSS), the function of the salivary glands is often considerably
reduced. Multiple innate immune pathways are likely dysregulated in the salivary gland …

The durability of infection-induced SARS-CoV-2 immunity has major implications for
reinfection and vaccine development. Here, we show a comprehensive profile of antibody, B …

Clonal hematopoiesis (CH) results from somatic genomic alterations that drive clonal
expansion of blood cells. Somatic gene mutations associated with hematologic …

The development of precision medicine approaches for diffuse large B cell lymphoma
(DLBCL) is confounded by its pronounced genetic, phenotypic, and clinical heterogeneity …

Age-related diseases are frequently linked to pathological immune dysfunction, including
excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human …

High-level expression of the transcription factor T-bet characterizes a phenotypically distinct
murine B cell population known as “age-associated B cells”(ABCs). T-bet–deficient mice …

The lymphocyte genome is prone to many threats, including programmed mutation during
differentiation, antigen-driven proliferation and residency in diverse microenvironments …

The use of genomics is firmly established in clinical practice, resulting in innovations across
a wide range of disciplines such as genetic screening, rare disease diagnosis and …

Somatic Mutations in “Benign” Disease DNA mutations occur in nearly every tissue
throughout the human life span and accumulate at various rates in different tissues …