[HTML][HTML] The role of lung macrophages in chronic obstructive pulmonary disease

J Wu, X Zhao, C Xiao, G Xiong, X Ye, L Li, Y Fang… - Respiratory …, 2022 - Elsevier
Chronic obstructive pulmonary disease (COPD) as a common, preventable and treatable
chronic respiratory disease in clinic, gets continuous deterioration and we can't take effective …

The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD

G Günes Günsel, TM Conlon, A Jeridi, R Kim… - Nature …, 2022 - nature.com
Extravasation of monocytes into tissue and to the site of injury is a fundamental
immunological process, which requires rapid responses via post translational modifications …

Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease

J Hey, M Paulsen, R Toth, D Weichenhan… - Nature …, 2021 - nature.com
Lung diseases, such as cystic fibrosis and COPD, are characterized by mucus obstruction
and chronic airway inflammation, but their mechanistic link remains poorly understood …

[HTML][HTML] Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease

TS Kapellos, K Baßler, W Fujii, C Nalkurthi, AC Schaar… - Cell reports, 2023 - cell.com
Systemic inflammation is established as part of late-stage severe lung disease, but
molecular, functional, and phenotypic changes in peripheral immune cells in early disease …

Targeting CCL2-CCR2 signaling pathway alleviates macrophage dysfunction in COPD via PI3K-AKT axis

Y Dong, Y Dong, C Zhu, L Yang, H Wang, J Li… - Cell Communication and …, 2024 - Springer
Background Chronic obstructive pulmonary disease (COPD) remains a leading cause of
morbidity and mortality worldwide, characterized by persistent respiratory symptoms and …

Tobacco smoke exposure recruits inflammatory airspace monocytes that establish permissive lung niches for Mycobacterium tuberculosis

B Corleis, CN Tzouanas, MH Wadsworth… - Science translational …, 2023 - science.org
Tobacco smoking doubles the risk of active tuberculosis (TB) and accounts for up to 20% of
all active TB cases globally. How smoking promotes lung microenvironments permissive to …

Surfactant protein D inhibits lipid-laden foamy macrophages and lung inflammation in chronic obstructive pulmonary disease

MH Hsieh, PC Chen, HY Hsu, JC Liu, YS Ho… - Cellular & Molecular …, 2023 - nature.com
Increased levels of surfactant protein D (SP-D) and lipid-laden foamy macrophages (FMs)
are frequently found under oxidative stress conditions and/or in patients with chronic …

Monocyte-derived alveolar macrophages are key drivers of smoke-induced lung inflammation and tissue remodeling

CT Wohnhaas, K Baßler, CK Watson, Y Shen… - Frontiers in …, 2024 - frontiersin.org
Smoking is a leading risk factor of chronic obstructive pulmonary disease (COPD), that is
characterized by chronic lung inflammation, tissue remodeling and emphysema. Although …

Identification of drug candidates targeting monocyte reprogramming in people living with HIV

R Knoll, L Bonaguro, JC Dos Santos… - Frontiers in …, 2023 - frontiersin.org
Introduction People living with HIV (PLHIV) are characterized by functional reprogramming
of innate immune cells even after long-term antiretroviral therapy (ART). In order to assess …

Single-cell transcriptomics highlights immunological dysregulations of monocytes in the pathobiology of COPD

Q Huang, Y Wang, L Zhang, W Qian, S Shen… - Respiratory …, 2022 - Springer
Background Chronic obstructive pulmonary disease (COPD) is a common respiratory
disease, whose pathogenetic complexity was strongly associated with aging/smoking and …