Simple Summary Omics technologies and targeted drugs are revolutionizing the clinical
oncology landscape, portending the promise of precision oncology. However, our abilities to …

RAS proteins regulate most aspects of cellular physiology. They are mutated in 30% of
human cancers and 4% of developmental disorders termed Rasopathies. They cycle …

Background Multidrug resistance (MDR) is a complex phenomenon that frequently leads to
chemotherapy failure during cancer treatment. The overexpression of ATP-binding cassette …

Combining single‐cell measurements of ERK activity dynamics with perturbations provides
insights into the MAPK network topology. We built circuits consisting of an optogenetic …

Xijiao Dihuang decoction combined with Yinqiao powder (XDD-YQP) is a classical
combination formula; however, its therapeutic effects in treating influenza viral pneumonia …

Background MicroRNA (miRNA) has been reported to play a critical regulatory role in
papillary thyroid carcinomas (PTC). However, the role of miR-221/222 in PTC remains …

We describe a small molecule ligand ACA-14 (2-hydroxy-5-{[(2-phenylcyclopropyl) carbonyl]
amino} benzoic acid) as an initial lead for the development of direct inhibitors of KRAS, a …

Background: Previous studies demonstrated that microRNA-92a (miR-92a) may serve as a
novel promising biomarker in colorectal cancer (CRC) patients. However, a comprehensive …

Autophagy is an evolutionary conserved process that recycles cellular materials in times of
nutrient restriction to maintain viability. In cancer therapeutics, the role of autophagy in …

Ras research has experienced a considerable boost in recent years, not least prompted by
the Ras initiative launched by the NCI in 2013 (https://www. cancer. gov/research/key …