Proteins in the karyopherin-β family mediate the majority of macromolecular transport
between the nucleus and the cytoplasm. Eleven of the 19 known human karyopherin-βs and …

The functional sperm is the key factor for species continuation. The process
spermatogenesis, to produce mature sperm is quite complex. It begins with the proliferation …

Nucleosomes compact and organize genetic material on a structural level. However, they
also alter local chromatin accessibility through changes in their position, through the …

The transport of histones from the cytoplasm to the nucleus of the cell, through the nuclear
membrane, is a cellular process that regulates the supply of new histones in the nucleus and …

Nucleosome assembly involves deposition of a heterotetramer of histones H3/H4 onto DNA
followed by two heterodimers of histones H2A/H2B. Cycles of nucleosome assembly and …

We report the crystal structure of nuclear import receptor Importin-9 bound to its cargo, the
histones H2A-H2B. Importin-9 wraps around the core, globular region of H2A-H2B to form …

ERj1p is a membrane protein of the endoplasmic reticulum (ER) that can recruit the ER
lumenal chaperone BiP to translating ribosomes. ERj1p can also modulate protein synthesis …

Histone chaperones are proteins that shield histones from nonspecific interactions until they
are assembled into chromatin. After their synthesis in the cytoplasm, histones are bound by …

Summary Karyopherin-β2 or Transportin-1 binds proline-tyrosine nuclear localization
signals (PY-NLSs) in its cargos. PY-NLSs are described by structural disorder, overall …

N-terminal tails of histones H3 and H4 are known to bind several different Importins to import
the histones into the cell nucleus. However, it is not known what binding elements in the …