Post-translational modifications in signal integration
YL Deribe, T Pawson, I Dikic - Nature structural & molecular biology, 2010 - nature.com
Post-translational modifications of proteins and the domains that recognize these
modifications have central roles in creating a highly dynamic relay system that reads and …
modifications have central roles in creating a highly dynamic relay system that reads and …
Protein intrinsic disorder-based liquid–liquid phase transitions in biological systems: Complex coacervates and membrane-less organelles
VN Uversky - Advances in colloid and interface science, 2017 - Elsevier
It is clear now that eukaryotic cells contain numerous membrane-less organelles, many of
which are formed in response to changes in the cellular environment. Being typically liquid …
which are formed in response to changes in the cellular environment. Being typically liquid …
Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs
Liquid–liquid phase separation (LLPS) is thought to contribute to the establishment of many
biomolecular condensates, eukaryotic cell structures that concentrate diverse …
biomolecular condensates, eukaryotic cell structures that concentrate diverse …
Phase transitions in the assembly of multivalent signalling proteins
Cells are organized on length scales ranging from ångström to micrometres. However, the
mechanisms by which ångström-scale molecular properties are translated to micrometre …
mechanisms by which ångström-scale molecular properties are translated to micrometre …
Minimalist design of an intrinsically disordered protein-mimicking scaffold for an artificial membraneless organelle
Liquid–liquid phase separation (LLPS) is an emerging and universal mechanism for
intracellular organization, particularly, by forming membraneless organelles (MLOs) hosting …
intracellular organization, particularly, by forming membraneless organelles (MLOs) hosting …
Phosphotyrosine signaling: evolving a new cellular communication system
WA Lim, T Pawson - Cell, 2010 - cell.com
Tyrosine phosphorylation controls many cellular functions. Yet the three-part toolkit that
regulates phosphotyrosine signaling—tyrosine kinases, phosphotyrosine phosphatases …
regulates phosphotyrosine signaling—tyrosine kinases, phosphotyrosine phosphatases …
[HTML][HTML] The human phosphatase interactome: An intricate family portrait
The concerted activities of kinases and phosphatases modulate the phosphorylation levels
of proteins, lipids and carbohydrates in eukaryotic cells. Despite considerable effort, we are …
of proteins, lipids and carbohydrates in eukaryotic cells. Despite considerable effort, we are …
Deciphering arginine methylation: Tudor tells the tale
Proteins can be modified by post-translational modifications such as phosphorylation,
methylation, acetylation and ubiquitylation, creating binding sites for specific protein …
methylation, acetylation and ubiquitylation, creating binding sites for specific protein …
In silico Prediction, Characterization, Molecular Docking, and Dynamic Studies on Fungal SDRs as Novel Targets for Searching Potential Fungicides Against …
Vascular wilt of tomato caused by Fusarium oxysporum f. sp. lycopersici (FOL) is one of the
most devastating diseases, that delimits the tomato production worldwide. Fungal short …
most devastating diseases, that delimits the tomato production worldwide. Fungal short …
Modular evolution of phosphorylation-based signalling systems
J Jin, T Pawson - … Transactions of the Royal Society B …, 2012 - royalsocietypublishing.org
Phosphorylation sites are formed by protein kinases ('writers'), frequently exert their effects
following recognition by phospho-binding proteins ('readers') and are removed by protein …
following recognition by phospho-binding proteins ('readers') and are removed by protein …