A platform for the synthesis of oxidation products of bilirubin

T Mujawar, P Sevelda, D Madea, P Klán… - Journal of the …, 2024 - ACS Publications
Bilirubin is the principal product of heme catabolism. High concentrations of the pigment are
neurotoxic, yet slightly elevated levels are beneficial. Being a potent antioxidant, oxidative …

Efficient Total Synthesis of Bilirubin IXα from Butyrolactone

F Chen, Y Chen, Z Luo, F Pan, X Zhao… - … Process Research & …, 2024 - ACS Publications
Bilirubin, a yellow pigment formed during the heme breakdown in the red blood cells, plays
a central role in the physiological processes of vertebrates. It is the main component of Bovis …

Photochemical Action Plots Reveal Red‐shifted Wavelength‐dependent Photoproduct Distributions

JA Carroll, F Pashley‐Johnson, H Frisch… - … A European Journal, 2024 - Wiley Online Library
Photochemical action plots are a powerful tool for mapping photochemical reaction
outcomes wavelength‐by‐wavelength. Typically, they map either the depletion of a reactant …

Photochemistry of (Z)-Isovinylneoxanthobilirubic Acid Methyl Ester, a Bilirubin Dipyrrinone Subunit: Femtosecond Transient Absorption and Stimulated Raman …

D Madea, T Mujawar, A Dvořák… - The Journal of …, 2022 - ACS Publications
Bilirubin (BR) is an essential metabolite formed by the catabolism of heme. Phototherapy
with blue-green light can be applied to reduce high concentrations of BR in blood and is …

Design and physico-chemical properties of unsymmetrically substituted dipyrromethenes and their complexes with boron (III) and zinc (II)

MB Berezin, SA Dogadaeva, EV Antina, MM Lukanov… - Dyes and …, 2022 - Elsevier
Unsymmetrically substituted boron (III) and zinc (II) dipyrromethenates were synthesized in
high yields, and the physico-chemical investigation results of them are presented …

Long chain fatty acid affects excited state branching in bilirubin-human serum protein Complex

Y Liu, H Pan, J Xu, J Chen - Chinese Journal of Chemical Physics, 2021 - pubs.aip.org
After binding to human serum albumin, bilirubin could undergo photoisomerization and
photo-induced cyclization process. The latter process would result the formation of a …

Rethinking uncaging: a new antiaromatic photocage driven by a gain of resonance energy

V Hermanns, M Scheurer, NF Kersten… - … A European Journal, 2021 - Wiley Online Library
Photoactivatable compounds for example photoswitches or photolabile protecting groups
(PPGs, photocages) for spatiotemporal light control, play a crucial role in different areas of …

Conformational control of the photodynamics of a bilirubin dipyrrinone subunit: Femtosecond spectroscopy combined with nonadiabatic simulations

J Janoš, D Madea, S Mahvidi, T Mujawar… - The Journal of …, 2020 - ACS Publications
The photochemistry of bilirubin has been extensively studied due to its importance in the
phototherapy of hyperbilirubinemia. In the present work, we investigated the ultrafast …

Highly emissive biological bilirubin molecules: shedding new light on the phototherapy scheme

AM El-Zohry, V Diez-Cabanes, M Pastore… - The Journal of …, 2021 - ACS Publications
Bilirubin (BR) is the main end-product of the hemoglobin catabolism. For decades, its
photophysics has been mainly discussed in terms of ultrafast deactivation of the excited …

Intramolecular hydrogen bonds interactions in the isomers of the bilirubin molecule: DFT and QTAIM analysis

ÁB Cruz, LG de Brito, PVB Leal… - Journal of Molecular …, 2023 - Springer
Context Bilirubin is an important molecule, used as a marker of some liver diseases, and it
can also be toxic and cause jaundice, especially in newborns. The main treatment for …